Reactome | CASR binds Ca2+

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CASR binds Ca2+ Show undefined attributes

authored	[InstanceEdit:420735] Jassal, Bijay, 2009-05-13
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:420735] Jassal, Bijay, 2009-05-13
dbId	420724
displayName	CASR binds Ca2+
edited	[InstanceEdit:420735] Jassal, Bijay, 2009-05-13
eventOf	[Pathway:R-HSA-420499] Class C/3 (Metabotropic glutamate/pheromone receptors) - Homo sapiens
followingEvent	[Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Homo sapiens [Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Homo sapiens
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [EntityWithAccessionedSequence:R-HSA-420719] CASR [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:420696] Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs [LiteratureReference:420691] The Ca2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells [LiteratureReference:420708] Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CASR binds Ca2+ Calcium-sensing receptor binds calcium
orthologousEvent	[Reaction:R-GGA-420724] CASR binds Ca2+ - Gallus gallus [Reaction:R-XTR-420724] CASR binds Ca2+ - Xenopus tropicalis [Reaction:R-SSC-420724] CASR binds Ca2+ - Sus scrofa [Reaction:R-BTA-420724] CASR binds Ca2+ - Bos taurus [Reaction:R-CFA-420724] CASR binds Ca2+ - Canis familiaris [Reaction:R-RNO-420724] CASR binds Ca2+ - Rattus norvegicus [Reaction:R-MMU-420724] CASR binds Ca2+ - Mus musculus
output	[Complex:R-HSA-420743] CASR:Ca2+ [plasma membrane]
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422381] D'Eustachio, P, 2009-05-29 07:44:22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-420724
summation	[Summation:420718] The parathyroid glands play a role in ion homeostasis by sen...
updateTrackers	[UpdateTracker:9776542] Update Tracker - [Reaction:420724] CASR binds Ca2+ - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776542] Update Tracker - [Reaction:420724] CASR binds Ca2+ - v75:[modifyText]
(hasEvent)	[Pathway:R-HSA-420499] Class C/3 (Metabotropic glutamate/pheromone receptors)
(precedingEvent)	[Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq [Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi