Reactome | CX3CR1 binds CX3CL1

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CX3CR1 binds CX3CL1 Show undefined attributes

authored	[InstanceEdit:375275] Jassal, Bijay, 2008-08-21
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:373366] Jassal, Bijay, 2008-07-16
dbId	373342
displayName	CX3CR1 binds CX3CL1
edited	[InstanceEdit:375493] D'Eustachio, P, 2008-09-01 11:58:31
eventOf	[Pathway:R-HSA-380108] Chemokine receptors bind chemokines - Homo sapiens
followingEvent	[Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-373368] CX3CL1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2980688] CX3CR1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:373364] Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion [LiteratureReference:373365] A new class of membrane-bound chemokine with a CX3C motif
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CX3CR1 binds CX3CL1
orthologousEvent	[Reaction:R-GGA-373342] CX3CR1 binds CX3CL1 - Gallus gallus [Reaction:R-DRE-373342] CX3CR1 binds CX3CL1 - Danio rerio [Reaction:R-BTA-373342] CX3CR1 binds CX3CL1 - Bos taurus [Reaction:R-CFA-373342] CX3CR1 binds CX3CL1 - Canis familiaris [Reaction:R-RNO-373342] CX3CR1 binds CX3CL1 - Rattus norvegicus [Reaction:R-MMU-373342] CX3CR1 binds CX3CL1 - Mus musculus
output	[Complex:R-HSA-373352] CX3CR1:CX3CL1 [plasma membrane]
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:375494] Bockaert, J, 2008-09-01 12:04:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-373342
summation	[Summation:373370] CX3CL1 (fractalkine) is a member of the chemokine superfamil...
updateTrackers	[UpdateTracker:9791118] Update Tracker - [Reaction:373342] CX3CR1 binds CX3CL1 - v32:[modifyText] [UpdateTracker:9780326] Update Tracker - [Reaction:373342] CX3CR1 binds CX3CL1 - v63:[modifyText] [UpdateTracker:9788102] Update Tracker - [Reaction:373342] CX3CR1 binds CX3CL1 - v44:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9791118] Update Tracker - [Reaction:373342] CX3CR1 binds CX3CL1 - v32:[modifyText] [UpdateTracker:9780326] Update Tracker - [Reaction:373342] CX3CR1 binds CX3CL1 - v63:[modifyText] [UpdateTracker:9788102] Update Tracker - [Reaction:373342] CX3CR1 binds CX3CL1 - v44:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-380108] Chemokine receptors bind chemokines
(precedingEvent)	[Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi