Reactome | Amino acid transport across the plasma membrane

Schema > Pathway > Entries

Amino acid transport across the plasma membrane Show undefined attributes

authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:352226] D'Eustachio, P, 2008-06-02 00:48:27
dbId	352230
displayName	Amino acid transport across the plasma membrane
edited	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
eventOf	[Pathway:R-HSA-9958863] SLC-mediated transport of amino acids - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20641] amino acid transport
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-352158] SLC16A10-mediated uptake of aromatic amino acids - Homo sapiens [Reaction:R-HSA-352119] SLC38A1 (ATA1)-mediated uptake of neutral amino acids - Homo sapiens [Reaction:R-HSA-352108] SLC38A2 (ATA2)-mediated uptake of neutral amino acids - Homo sapiens [Reaction:R-HSA-352174] SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine - Homo sapiens [Reaction:R-HSA-352136] SLC38A4 (ATA3)-mediated uptake of arginine and lysine - Homo sapiens [Reaction:R-HSA-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Homo sapiens [Reaction:R-HSA-352103] SLC43A1 (LAT3)-mediated uptake of large neutral amino acids - Homo sapiens [Reaction:R-HSA-352107] SLC43A2 (LAT4)-mediated uptake of large neutral amino acids - Homo sapiens [Reaction:R-HSA-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Homo sapiens [Reaction:R-HSA-352059] SLC6A15-mediated amino acid uptake - Homo sapiens [Reaction:R-HSA-352052] SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-351987] SLC6A6-mediated uptake of taurine and beta-alanine - Homo sapiens [Reaction:R-HSA-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-352191] SLC7A8-mediated uptake of neutral amino acids - Homo sapiens [Reaction:R-HSA-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Homo sapiens [Reaction:R-HSA-352354] SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine - Homo sapiens [Reaction:R-HSA-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Homo sapiens [Reaction:R-HSA-352371] SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine - Homo sapiens [Reaction:R-HSA-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Homo sapiens [Reaction:R-HSA-352385] SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane - Homo sapiens [Reaction:R-HSA-375417] SLC36A1-mediated uptake of glycine, proline, and alanine - Homo sapiens [Reaction:R-HSA-375405] SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-8870354] SLC36A4 transports extracellular L-Pro to the cytosol - Homo sapiens [Reaction:R-HSA-375487] SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Homo sapiens [Reaction:R-HSA-375790] SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids - Homo sapiens [Reaction:R-HSA-375768] SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids - Homo sapiens [Reaction:R-HSA-375770] SLC7A3 (CAT-3)-mediated uptake of cationic amino acids - Homo sapiens [Reaction:R-HSA-376200] SLC7A10-mediated uptake of small neutral amino acids - Homo sapiens [Reaction:R-HSA-378513] SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate - Homo sapiens [Reaction:R-HSA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Homo sapiens [Reaction:R-HSA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Homo sapiens [Reaction:R-HSA-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Homo sapiens [BlackBoxEvent:R-HSA-8959781] SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-12-18
literatureReference	[LiteratureReference:352222] Amino acid transport across mammalian intestinal and renal epithelia
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Amino acid transport across the plasma membrane
orthologousEvent	[Pathway:R-PFA-352230] Amino acid transport across the plasma membrane - Plasmodium falciparum [Pathway:R-SCE-352230] Amino acid transport across the plasma membrane - Saccharomyces cerevisiae [Pathway:R-SPO-352230] Amino acid transport across the plasma membrane - Schizosaccharomyces pombe [Pathway:R-DDI-352230] Amino acid transport across the plasma membrane - Dictyostelium discoideum [Pathway:R-MMU-352230] Amino acid transport across the plasma membrane - Mus musculus [Pathway:R-RNO-352230] Amino acid transport across the plasma membrane - Rattus norvegicus [Pathway:R-CFA-352230] Amino acid transport across the plasma membrane - Canis familiaris [Pathway:R-BTA-352230] Amino acid transport across the plasma membrane - Bos taurus [Pathway:R-SSC-352230] Amino acid transport across the plasma membrane - Sus scrofa [Pathway:R-DRE-352230] Amino acid transport across the plasma membrane - Danio rerio [Pathway:R-XTR-352230] Amino acid transport across the plasma membrane - Xenopus tropicalis [Pathway:R-GGA-352230] Amino acid transport across the plasma membrane - Gallus gallus [Pathway:R-DME-352230] Amino acid transport across the plasma membrane - Drosophila melanogaster [Pathway:R-CEL-352230] Amino acid transport across the plasma membrane - Caenorhabditis elegans
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03 [InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-352230
summation	[Summation:352223] Amino acid transport across plasma membranes is critical to ...
updateTrackers	[UpdateTracker:9790493] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v33:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9791730] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v26:[addHasEvent, modifyText] [UpdateTracker:9785265] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v52:[updateContainedRLE] [UpdateTracker:9781738] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v60:[addHasEvent] [UpdateTracker:9791393] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v30:[updateContainedRLE] [UpdateTracker:9784378] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v54:[updateContainedRLE] [UpdateTracker:9964712] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v94:[addHasEvent] [UpdateTracker:9780314] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v63:[updateContainedRLE] [UpdateTracker:9791676] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v27:[addHasEvent, updateContainedRLE] [UpdateTracker:9786839] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v47:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-9958863] SLC-mediated transport of amino acids

(updatedInstance)

[UpdateTracker:9790493] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v33:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9791730] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v26:[addHasEvent, modifyText]
[UpdateTracker:9785265] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v52:[updateContainedRLE]
[UpdateTracker:9781738] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v60:[addHasEvent]
[UpdateTracker:9791393] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v30:[updateContainedRLE]
[UpdateTracker:9784378] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v54:[updateContainedRLE]
[UpdateTracker:9964712] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v94:[addHasEvent]
[UpdateTracker:9780314] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v63:[updateContainedRLE]
[UpdateTracker:9791676] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v27:[addHasEvent, updateContainedRLE]
[UpdateTracker:9786839] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v47:[updateContainedRLE]

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