Reactome | SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane

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SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane Show undefined attributes

authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:352388] amino acid transmembrane transporter activity of SLC1A5 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:352377] D'Eustachio, P, 2008-06-02 20:14:10
dbId	352379
deleted	[Deleted:602195] Deletion of instance: 352389
displayName	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
edited	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
eventOf	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-352036] L-Ala [extracellular region] [SimpleEntity:R-ALL-29472] L-Gln [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:352381] Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance [LiteratureReference:352378] Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
negativePrecedingEvent	[NegativePrecedingEvent:9963203] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine [NegativePrecedingEvent:9963207] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963227] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963295] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine [NegativePrecedingEvent:9963279] Futile Cycle: SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane [NegativePrecedingEvent:9963360] Futile Cycle: SLC38A1 (ATA1)-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963330] Futile Cycle: SLC38A2 (ATA2)-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963333] Futile Cycle: SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine [NegativePrecedingEvent:9963362] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [NegativePrecedingEvent:9963352] Futile Cycle: SLC6A15-mediated amino acid uptake [NegativePrecedingEvent:9963381] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963378] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids
orthologousEvent	[Reaction:R-MMU-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Mus musculus [Reaction:R-RNO-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Rattus norvegicus [Reaction:R-CFA-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Canis familiaris [Reaction:R-BTA-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Bos taurus [Reaction:R-SSC-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Sus scrofa [Reaction:R-DRE-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Danio rerio [Reaction:R-XTR-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Xenopus tropicalis [Reaction:R-DME-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Drosophila melanogaster [Reaction:R-CEL-352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - Caenorhabditis elegans
output	[SimpleEntity:R-ALL-29432] L-Ala [cytosol] [SimpleEntity:R-ALL-212615] L-Gln [extracellular region] [SimpleEntity:R-ALL-83910] Na+ [cytosol] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
releaseDate	2008-06-30
reverseReaction	[Reaction:R-HSA-352385] SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-352379
summation	[Summation:352391] SLC1A5, associated with the plasma membrane, mediates the ex...
updateTrackers	[UpdateTracker:9790600] Update Tracker - [Reaction:352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - v33:[addLiteratureReference]

Referrals

(precedingEvent)	[NegativePrecedingEvent:9963307] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963278] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963318] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963308] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963317] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963306] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963298] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963300] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963284] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963283] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963313] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963292] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
(hasEvent)	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane
(replacementInstances)	[Deleted:602195] Deletion of instance: 352389
(updatedInstance)	[UpdateTracker:9790600] Update Tracker - [Reaction:352379] SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - v33:[addLiteratureReference]

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