Reactome | SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine

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SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine Show undefined attributes

authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:352361] amino acid transmembrane transporter activity of SLC1A4 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:352351] D'Eustachio, P, 2008-06-02 18:13:12
crossReference	[DatabaseIdentifier:12667959] RHEA:29575
dbId	352347
deleted	[Deleted:602193] Deletion of instance: 352370
displayName	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine
edited	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
eventOf	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane - Homo sapiens
input	[DefinedSet:R-ALL-352355] alanine, serine, threonine, or cysteine [cytosol] [SimpleEntity:R-ALL-352002] L-Ser [extracellular region] [SimpleEntity:R-ALL-83910] Na+ [cytosol] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:352345] ASCT-1 is a neutral amino acid exchanger with chloride channel activity [LiteratureReference:352362] Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family [LiteratureReference:352348] Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine
negativePrecedingEvent	[NegativePrecedingEvent:9963232] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine [NegativePrecedingEvent:9963218] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963275] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine [NegativePrecedingEvent:9963313] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963339] Futile Cycle: SLC36A1-mediated uptake of glycine, proline, and alanine [NegativePrecedingEvent:9963336] Futile Cycle: SLC38A1 (ATA1)-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963343] Futile Cycle: SLC38A2 (ATA2)-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963359] Futile Cycle: SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine [NegativePrecedingEvent:9963369] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [NegativePrecedingEvent:9963358] Futile Cycle: SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963346] Futile Cycle: SLC6A15-mediated amino acid uptake [NegativePrecedingEvent:9963391] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963422] Futile Cycle: SLC7A10-mediated uptake of small neutral amino acids [NegativePrecedingEvent:9963418] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [NegativePrecedingEvent:9963402] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids
orthologousEvent	[Reaction:R-MMU-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Mus musculus [Reaction:R-RNO-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Rattus norvegicus [Reaction:R-CFA-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Canis familiaris [Reaction:R-BTA-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Bos taurus [Reaction:R-SSC-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Sus scrofa [Reaction:R-DRE-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Danio rerio [Reaction:R-XTR-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Xenopus tropicalis [Reaction:R-GGA-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Gallus gallus [Reaction:R-DME-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Drosophila melanogaster [Reaction:R-CEL-352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - Caenorhabditis elegans
output	[DefinedSet:R-ALL-352359] alanine, serine, threonine, or cysteine [extracellular region] [SimpleEntity:R-ALL-200736] L-Ser [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-352347
summation	[Summation:352350] SLC1A4, associated with the plasma membrane, mediates the ex...
updateTrackers	[UpdateTracker:9790609] Update Tracker - [Reaction:352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - v33:[addLiteratureReference]

Referrals

(precedingEvent)	[NegativePrecedingEvent:9963311] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963214] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963293] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963211] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963220] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963202] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963304] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963227] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963200] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963315] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963305] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963301] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963291] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963212] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963287] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine
(hasEvent)	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane
(replacementInstances)	[Deleted:602193] Deletion of instance: 352370
(updatedInstance)	[UpdateTracker:9790609] Update Tracker - [Reaction:352347] SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - v33:[addLiteratureReference]

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