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Amino acid transport across the plasma membrane
Stable Identifier
R-HSA-352230
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Amino acid transport across the plasma membrane (Homo sapiens)
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Amino acid transport across plasma membranes is critical to the uptake of these molecules from the gut, to their reabsortion in the kidney proximal tubulues, and to their distribution to cells in which they are required for the synthesis of proteins and of amino acid derived small molecules such as neurotransmitters. Physiological studies have defined 18 "systems" that mediate amino acid transport, each characterized by its amino acid substrates, as well as its pH sensitivity and its association (or not) with ion transport. More recently, molecular cloning studies have allowed the identification of the plasma membrane transport proteins that mediate these reactions. Amino acid uptake mediated by 17 of these transporters is annotated here (Broer 2008).
Literature References
PubMed ID
Title
Journal
Year
18195088
Amino acid transport across mammalian intestinal and renal epithelia
Broer, S
Physiol Rev
2008
Participants
Events
SLC16A10-mediated uptake of aromatic amino acids
(Homo sapiens)
SLC38A1 (ATA1)-mediated uptake of neutral amino acids
(Homo sapiens)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids
(Homo sapiens)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine
(Homo sapiens)
SLC38A4 (ATA3)-mediated uptake of arginine and lysine
(Homo sapiens)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine
(Homo sapiens)
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids
(Homo sapiens)
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids
(Homo sapiens)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
(Homo sapiens)
SLC6A15-mediated amino acid uptake
(Homo sapiens)
SLC6A18 transports Gly from extracellular region to cytosol
(Homo sapiens)
SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol
(Homo sapiens)
SLC6A6-mediated uptake of taurine and beta-alanine
(Homo sapiens)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
(Homo sapiens)
SLC7A8-mediated uptake of neutral amino acids
(Homo sapiens)
SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
(Homo sapiens)
SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine
(Homo sapiens)
SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine
(Homo sapiens)
SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine
(Homo sapiens)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
(Homo sapiens)
SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane
(Homo sapiens)
SLC36A1-mediated uptake of glycine, proline, and alanine
(Homo sapiens)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol
(Homo sapiens)
SLC36A4 transports extracellular L-Pro to the cytosol
(Homo sapiens)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol
(Homo sapiens)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
(Homo sapiens)
SLC7A1 (CAT-1)-mediated uptake of cationic amino acids
(Homo sapiens)
SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids
(Homo sapiens)
SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids
(Homo sapiens)
SLC7A3 (CAT-3)-mediated uptake of cationic amino acids
(Homo sapiens)
SLC7A10-mediated uptake of small neutral amino acids
(Homo sapiens)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate
(Homo sapiens)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine
(Homo sapiens)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
(Homo sapiens)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
(Homo sapiens)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix
(Homo sapiens)
Participates
as an event of
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Event Information
Go Biological Process
amino acid transport (0006865)
Orthologous Events
Amino acid transport across the plasma membrane (Bos taurus)
Amino acid transport across the plasma membrane (Caenorhabditis elegans)
Amino acid transport across the plasma membrane (Canis familiaris)
Amino acid transport across the plasma membrane (Danio rerio)
Amino acid transport across the plasma membrane (Dictyostelium discoideum)
Amino acid transport across the plasma membrane (Drosophila melanogaster)
Amino acid transport across the plasma membrane (Gallus gallus)
Amino acid transport across the plasma membrane (Mus musculus)
Amino acid transport across the plasma membrane (Plasmodium falciparum)
Amino acid transport across the plasma membrane (Rattus norvegicus)
Amino acid transport across the plasma membrane (Saccharomyces cerevisiae)
Amino acid transport across the plasma membrane (Sus scrofa)
Amino acid transport across the plasma membrane (Xenopus tropicalis)
Authored
D'Eustachio, P (2008-06-03)
Reviewed
Jassal, B (2008-06-03)
Created
D'Eustachio, P (2008-06-02)
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