Reactome | SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol

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SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:375470] amino acid transmembrane transporter activity of SLC6A19 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:375485] D'Eustachio, P, 2008-08-29 20:22:39
crossReference	[DatabaseIdentifier:9956823] RHEA:29265 [DatabaseIdentifier:12667957] RHEA:29263 [DatabaseIdentifier:12667959] RHEA:29575 [DatabaseIdentifier:12667958] RHEA:68228 [DatabaseIdentifier:12667980] RHEA:68248 [DatabaseIdentifier:12667962] RHEA:68240 [DatabaseIdentifier:12667954] RHEA:29283 [DatabaseIdentifier:12667981] RHEA:68252 [DatabaseIdentifier:12667966] RHEA:29267 [DatabaseIdentifier:12667979] RHEA:68244 [DatabaseIdentifier:12667956] RHEA:68232 [DatabaseIdentifier:12667538] RHEA:68236 [DatabaseIdentifier:12667965] RHEA:29275 [DatabaseIdentifier:9956829] RHEA:29269 [DatabaseIdentifier:9956828] RHEA:29277 [DatabaseIdentifier:9956846] RHEA:29285 [DatabaseIdentifier:9956843] RHEA:29577 [DatabaseIdentifier:9956818] RHEA:68234 [DatabaseIdentifier:9956842] RHEA:68241
dbId	375473
diseaseReaction	[FailedReaction:R-HSA-5659734] Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol - Homo sapiens
displayName	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
edited	[InstanceEdit:377486] D'Eustachio, P, 2008-09-12 21:44:24
eventOf	[Pathway:R-HSA-442660] SLC-mediated transport of neurotransmitters - Homo sapiens [Pathway:R-HSA-352230] Amino acid transport across the plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-428625] Vesicular inhibitory amino acid transport - Homo sapiens
input	[SimpleEntity:R-ALL-74113] Na+ [extracellular region] [DefinedSet:R-ALL-375458] neutral amino acids [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:375453] Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19 [LiteratureReference:375462] Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol SLC6A19-mediated uptake of neutral amino acids
negativePrecedingEvent	[NegativePrecedingEvent:9963217] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine [NegativePrecedingEvent:9963223] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963291] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963281] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine [NegativePrecedingEvent:9963284] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963288] Futile Cycle: SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane [NegativePrecedingEvent:9963389] Futile Cycle: SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
orthologousEvent	[Reaction:R-MMU-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Mus musculus [Reaction:R-RNO-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-CFA-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Canis familiaris [Reaction:R-BTA-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Bos taurus [Reaction:R-SSC-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Sus scrofa [Reaction:R-DRE-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Danio rerio [Reaction:R-XTR-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-GGA-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Gallus gallus [Reaction:R-DME-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-PFA-375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - Plasmodium falciparum
output	[SimpleEntity:R-ALL-83910] Na+ [cytosol] [DefinedSet:R-ALL-375481] neutral amino acids [cytosol]
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-375473
summation	[Summation:375461] SLC6A19 mediates the uptake of neutral amino acids across th...
updateTrackers	[UpdateTracker:9784048] Update Tracker - [Reaction:375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - v54:[modifyText] [UpdateTracker:9785099] Update Tracker - [Reaction:375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - v52:[modifyText]

Referrals

(precedingEvent)	[NegativePrecedingEvent:9963381] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963407] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963391] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963392] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963396] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963403] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963406] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [Reaction:R-HSA-428625] Vesicular inhibitory amino acid transport
(hasEvent)	[Pathway:R-HSA-442660] SLC-mediated transport of neurotransmitters [Pathway:R-HSA-352230] Amino acid transport across the plasma membrane
(normalReaction)	[FailedReaction:R-HSA-5659734] Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol
(updatedInstance)	[UpdateTracker:9784048] Update Tracker - [Reaction:375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - v54:[modifyText] [UpdateTracker:9785099] Update Tracker - [Reaction:375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - v52:[modifyText]

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