Reactome | SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane

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SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane Show undefined attributes

authored	[InstanceEdit:386986] D'Eustachio, P, 2008-11-29 15:37:01
catalystActivity	[CatalystActivity:379423] amino acid transmembrane transporter activity of SLC7A7:SLC3A2 heterodimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:379411] D'Eustachio, P, 2008-10-28 22:22:39
crossReference	[DatabaseIdentifier:12667985] RHEA:70831 [DatabaseIdentifier:9960121] RHEA:70832
dbId	379415
diseaseReaction	[FailedReaction:R-HSA-5660910] Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane - Homo sapiens
displayName	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
edited	[InstanceEdit:386986] D'Eustachio, P, 2008-11-29 15:37:01
eventOf	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29468] L-Arg [cytosol] [SimpleEntity:R-ALL-351964] L-Leu [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:379414] Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine
negativePrecedingEvent	[NegativePrecedingEvent:9963354] Futile Cycle: SLC38A4 (ATA3)-mediated uptake of arginine and lysine [NegativePrecedingEvent:9963355] Futile Cycle: SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963416] Futile Cycle: SLC7A1 (CAT-1)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963413] Futile Cycle: SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963385] Futile Cycle: SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963390] Futile Cycle: SLC7A3 (CAT-3)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963408] Futile Cycle: SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
orthologousEvent	[Reaction:R-DME-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Drosophila melanogaster [Reaction:R-XTR-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Xenopus tropicalis [Reaction:R-DRE-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Danio rerio [Reaction:R-SSC-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Sus scrofa [Reaction:R-BTA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Bos taurus [Reaction:R-RNO-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Rattus norvegicus [Reaction:R-MMU-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Mus musculus
output	[SimpleEntity:R-ALL-351977] L-Arg [extracellular region] [SimpleEntity:R-ALL-29588] L-Leu [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:383343] Jassal, Bijay, 2008-11-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-379415
summation	[Summation:379410] SLC7A7 as a heterodimer with SLC3A2 in the plasma membrane m...
updateTrackers	[UpdateTracker:9785012] Update Tracker - [Reaction:379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - v52:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785012] Update Tracker - [Reaction:379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - v52:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5660910] Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane
(hasEvent)	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane
(precedingEvent)	[NegativePrecedingEvent:9963420] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963414] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963425] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963404] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963400] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963375] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963379] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane

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