Reactome | SLC7A1 (CAT-1)-mediated uptake of cationic amino acids

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SLC7A1 (CAT-1)-mediated uptake of cationic amino acids Show undefined attributes

authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:375796] amino acid transmembrane transporter activity of SLC7A1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:375778] D'Eustachio, P, 2008-09-04 22:11:07
crossReference	[DatabaseIdentifier:12667934] RHEA:70935 [DatabaseIdentifier:12667493] RHEA:32143 [DatabaseIdentifier:12667986] RHEA:71199 [DatabaseIdentifier:9960040] RHEA:32145 [DatabaseIdentifier:9960041] RHEA:70937 [DatabaseIdentifier:9960039] RHEA:71201
dbId	375776
displayName	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids
edited	[InstanceEdit:377486] D'Eustachio, P, 2008-09-12 21:44:24
eventOf	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane - Homo sapiens
input	[CandidateSet:R-ALL-375765] L-Arg, L-Lys, L-Orn [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:352222] Amino acid transport across mammalian intestinal and renal epithelia [LiteratureReference:375761] Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties [LiteratureReference:375780] Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1 [LiteratureReference:375767] Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids
negativePrecedingEvent	[NegativePrecedingEvent:9963417] Futile Cycle: SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [NegativePrecedingEvent:9963425] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
orthologousEvent	[Reaction:R-DDI-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Dictyostelium discoideum [Reaction:R-DME-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Drosophila melanogaster [Reaction:R-GGA-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Gallus gallus [Reaction:R-XTR-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Xenopus tropicalis [Reaction:R-DRE-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Danio rerio [Reaction:R-SSC-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Sus scrofa [Reaction:R-BTA-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Bos taurus [Reaction:R-CFA-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Canis familiaris [Reaction:R-RNO-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Rattus norvegicus [Reaction:R-MMU-375776] SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - Mus musculus
output	[CandidateSet:R-ALL-375781] L-Arg, L-Lys, L-Orn [cytosol]
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-375776
summation	[Summation:375787] SLC7A1 mediates the uptake of cationic amino acids across th...

Referrals

(precedingEvent)	[NegativePrecedingEvent:9963597] Futile Cycle: SLC7A1 (CAT-1)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963387] Futile Cycle: SLC7A1 (CAT-1)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963416] Futile Cycle: SLC7A1 (CAT-1)-mediated uptake of cationic amino acids
(hasEvent)	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane

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