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Schema
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Reaction
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Entries
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
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authored
[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity
[CatalystActivity:352233] L-amino acid transmembrane transporter activity of SLC7A5:SLC3A2 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:352226] D'Eustachio, P, 2008-06-02 00:48:27
crossReference
[DatabaseIdentifier:12667561] RHEA:29703
[DatabaseIdentifier:12667933] RHEA:72807
[DatabaseIdentifier:12667560] RHEA:70943
[DatabaseIdentifier:12667951] RHEA:70939
[DatabaseIdentifier:12667950] RHEA:70719
[DatabaseIdentifier:12667949] RHEA:27950
[DatabaseIdentifier:12667562] RHEA:73011
[DatabaseIdentifier:12667953] RHEA:70947
[DatabaseIdentifier:12667952] RHEA:68572
[DatabaseIdentifier:9917062] RHEA:73011
[DatabaseIdentifier:9917063] RHEA:29703
[DatabaseIdentifier:9929648] RHEA:68572
[DatabaseIdentifier:9929649] RHEA:72807
[DatabaseIdentifier:9929639] RHEA:70947
[DatabaseIdentifier:9929646] RHEA:27950
[DatabaseIdentifier:9929644] RHEA:70939
[DatabaseIdentifier:9917055] RHEA:70943
[DatabaseIdentifier:9929643] RHEA:70719
dbId
352232
displayName
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
edited
[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
eventOf
[Pathway:R-HSA-71240] Tryptophan catabolism - Homo sapiens
[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane - Homo sapiens
followingEvent
[Reaction:R-HSA-198563] IDO1 dioxygenates L-Trp to NFK - Homo sapiens
[Reaction:R-HSA-71188] TDO tetramer dioxygenates L-Trp to NFK - Homo sapiens
[Reaction:R-HSA-888614] IDO2 dioxygenates L-Trp to NFK - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:5083556] L-alpha-amino acid transmembrane transport
input
[DefinedSet:R-ALL-352229] ligands of SLC7A5 [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:352225] Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function
[LiteratureReference:352184] Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids
[LiteratureReference:9929614] Functional characterization of tyrosine transport in fibroblast cells from healthy controls
maxDepth
1
modified
[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
L-leucine(in) = L-leucine(out)
L-valine(in) = L-valine(out)
L-tyrosine(in) = L-tyrosine(out)
L-histidine(in) = L-histidine(out)
L-tryptophan(in) = L-tryptophan(out)
L-phenylalanine(in) = L-phenylalanine(out)
L-methionine(in) = L-methionine(out)
L-isoleucine(in) = L-isoleucine(out)
L-alanine(in) = L-alanine(out)
negativePrecedingEvent
[NegativePrecedingEvent:9963225] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[NegativePrecedingEvent:9963221] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine
[NegativePrecedingEvent:9963311] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine
[NegativePrecedingEvent:9963296] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine
[NegativePrecedingEvent:9963319] Futile Cycle: SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane
[NegativePrecedingEvent:9963428] Futile Cycle: SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
orthologousEvent
[Reaction:R-MMU-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Mus musculus
[Reaction:R-CFA-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Canis familiaris
[Reaction:R-BTA-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Bos taurus
[Reaction:R-SSC-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Sus scrofa
[Reaction:R-DRE-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Danio rerio
[Reaction:R-XTR-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Xenopus tropicalis
[Reaction:R-DME-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Drosophila melanogaster
[Reaction:R-RNO-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Rattus norvegicus
output
[DefinedSet:R-ALL-352227] ligands of SLC7A5 [cytosol]
releaseDate
2008-06-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-352232
summation
[Summation:352231] SLC7A5, complexed with SLC3A2 in the plasma membrane, mediat...
updateTrackers
[UpdateTracker:9939756] Update Tracker - [Reaction:352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - v92:[modifyText, removeLiteratureReference]
Referrals
(precedingEvent)
[NegativePrecedingEvent:9963601] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
[NegativePrecedingEvent:9963418] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
[NegativePrecedingEvent:9963386] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
[NegativePrecedingEvent:9963405] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
[NegativePrecedingEvent:9963429] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
[NegativePrecedingEvent:9963376] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
[NegativePrecedingEvent:9963371] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
[Reaction:R-HSA-198563] IDO1 dioxygenates L-Trp to NFK
[Reaction:R-HSA-71188] TDO tetramer dioxygenates L-Trp to NFK
[Reaction:R-HSA-888614] IDO2 dioxygenates L-Trp to NFK
(hasEvent)
[Pathway:R-HSA-71240] Tryptophan catabolism
[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane
(updatedInstance)
[UpdateTracker:9939756] Update Tracker - [Reaction:352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - v92:[modifyText, removeLiteratureReference]
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