Reactome | SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

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SLC6A12 (BGT-1)-mediated uptake of GABA and betaine Show undefined attributes

authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:351984] amino acid transmembrane transporter activity of SLC6A12 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:352012] D'Eustachio, P, 2008-05-29 20:27:07
crossReference	[DatabaseIdentifier:9956813] RHEA:71176
dbId	352029
displayName	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
edited	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
eventOf	[Pathway:R-HSA-888593] Reuptake of GABA - Homo sapiens [Pathway:R-HSA-352230] Amino acid transport across the plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen - Homo sapiens
input	2 × [SimpleEntity:R-ALL-188972] Cl- [extracellular region] [DefinedSet:R-ALL-352007] ligands of SLC6A12 (BGT-1) [extracellular region] 3 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:352038] Functional characterization of the Betaine/gamma-aminobutyric acid transporter BGT-1 expressed in Xenopus oocytes [LiteratureReference:351985] Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
orthologousEvent	[Reaction:R-PFA-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Plasmodium falciparum [Reaction:R-GGA-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Gallus gallus [Reaction:R-XTR-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Xenopus tropicalis [Reaction:R-DRE-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Danio rerio [Reaction:R-SSC-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Sus scrofa [Reaction:R-BTA-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Bos taurus [Reaction:R-CFA-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Canis familiaris [Reaction:R-RNO-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Rattus norvegicus [Reaction:R-MMU-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Mus musculus
output	2 × [SimpleEntity:R-ALL-352022] Cl- [cytosol] [DefinedSet:R-ALL-351982] ligands of SLC6A12 (BGT-1) [cytosol] 3 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
revised	[InstanceEdit:918258] Mahajan, SS, 2010-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-352029
summation	[Summation:352004] The plasma membrane transport protein SLC6A12 (BGT-1) mediat...

Referrals

(hasEvent)	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane [Pathway:R-HSA-888593] Reuptake of GABA
(precedingEvent)	[Reaction:R-HSA-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen