Reactome | SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine

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SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine Show undefined attributes

authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:9028795] amino acid transmembrane transporter activity of SLC38A5 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:352159] D'Eustachio, P, 2008-05-31 19:54:14
crossReference	[DatabaseIdentifier:12667972] RHEA:71127 [DatabaseIdentifier:12667977] RHEA:71131 [DatabaseIdentifier:12667976] RHEA:71163 [DatabaseIdentifier:12667973] RHEA:71159 [DatabaseIdentifier:12667975] RHEA:71135 [DatabaseIdentifier:12667974] RHEA:71167 [DatabaseIdentifier:9960022] RHEA:71160 [DatabaseIdentifier:9960028] RHEA:71164 [DatabaseIdentifier:9960019] RHEA:71168 [DatabaseIdentifier:9960026] RHEA:71128 [DatabaseIdentifier:9960024] RHEA:71132
dbId	352182
displayName	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine
edited	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
eventOf	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [DefinedSet:R-ALL-352178] ligands of SLC38A5 [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:352141] Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine
negativePrecedingEvent	[NegativePrecedingEvent:9963204] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963315] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963303] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine [NegativePrecedingEvent:9963306] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963314] Futile Cycle: SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane
orthologousEvent	[Reaction:R-XTR-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Xenopus tropicalis [Reaction:R-DRE-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Danio rerio [Reaction:R-SSC-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Sus scrofa [Reaction:R-BTA-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Bos taurus [Reaction:R-CFA-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Canis familiaris [Reaction:R-RNO-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Rattus norvegicus [Reaction:R-MMU-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Mus musculus
output	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [DefinedSet:R-ALL-352175] ligands of SLC38A5 [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-HSA-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-352182
summation	[Summation:352185] SLC38A5 (SN2), associated with the plasma membrane, mediates...
updateTrackers	[UpdateTracker:9780169] Update Tracker - [Reaction:352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - v63:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9780169] Update Tracker - [Reaction:352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - v63:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane
(precedingEvent)	[NegativePrecedingEvent:9963595] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [NegativePrecedingEvent:9963329] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [NegativePrecedingEvent:9963332] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [NegativePrecedingEvent:9963338] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [NegativePrecedingEvent:9963369] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [NegativePrecedingEvent:9963344] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [NegativePrecedingEvent:9963362] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine

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