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PIK3R1 [plasma membrane]
Stable Identifier
R-BTA-198365
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
PIK3R1, P23727
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
BCAP Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
p-CD19:VAV binds PI3K and GRB2 (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
BCAP Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
BCAP Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:P23727
Gene Names
PIK3R1
Reference Genes
BioGPS Gene:282307 PIK3R1
ENSEMBL:ENSBTAG00000010989
ENSEMBL:ENSBTAG00000010989.6 PIK3R1
KEGG Gene (Bos taurus):282307 PIK3R1
Monarch:282307 PIK3R1
NCBI Gene:282307 PIK3R1
Reference Transcript
RefSeq:NM_174575.1 PIK3R1
RefSeq:XM_005221436.3 PIK3R1
Other Identifiers
282307
GO:0001678
GO:0005068
GO:0005158
GO:0005159
GO:0005515
GO:0005634
GO:0005942
GO:0005943
GO:0006351
GO:0006355
GO:0006629
GO:0006886
GO:0006913
GO:0007155
GO:0007165
GO:0008286
GO:0012501
GO:0015031
GO:0023052
GO:0032869
GO:0033120
GO:0034446
GO:0034976
GO:0035014
GO:0042307
GO:0042802
GO:0043066
GO:0043125
GO:0043226
GO:0043491
GO:0043548
GO:0043560
GO:0045944
GO:0046326
GO:0046854
GO:0046935
GO:0048009
GO:0050821
GO:0055085
GO:0060090
GO:0072659
GO:0098772
GO:0140767
GO:0141038
GO:1900103
GO:1903078
Participates
as a component of
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Other forms of this molecule
PIK3R1 [cytosol]
PIK3R1 [cytosol]
Inferred From
PIK3R1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_005221493.1
,
NP_777000.1
OpenTargets
ENSG00000145675
Ensembl
ENSBTAT00000014594
,
ENSBTAG00000010989
,
ENSBTAP00000014594
VGNC
32894
PDB
6OCO
,
6G6W
,
1BFI
,
1OO3
,
6D85
,
6R4R
,
5DXU
,
6MRP
,
6D86
,
1QAD
,
2PNB
,
7JIS
,
5T8F
,
5DXH
,
6OCU
,
6D81
,
2PNA
,
2PNI
,
6D87
,
1PNJ
,
8BCY
,
6D82
,
1OO4
,
1BFJ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09619 PDGFRB
3
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.725
6
UniProt:P23727
3
PIK3R1 [plasma membrane]
(R-BTA-198365)
PIK3R1 [cytosol]
(R-BTA-74789)
PIK3R1 [cytosol]
(R-BTA-3080572)
0.624
4
UniProt:P20339 RAB5A
7
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
RAB5A [cytosol]
(R-HSA-2201187)
GGC-RAB5A [macropinosome membrane]
(R-HSA-9837697)
RAB5A [endosome membrane]
(R-HSA-452257)
RAB5A [early endosome membrane]
(R-HSA-2130175)
0.558
5
UniProt:P32871
1
PIK3CA [cytosol]
(R-BTA-74787)
0.524
4
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