Reactome | SUN2 [nuclear envelope]

SUN2 [nuclear envelope]

Stable Identifier

R-HSA-912382

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

SUN domain-containing protein 2, SUN2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UH99 SUN2

Gene Names

SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B

Chain

chain:1-717

Reference Genes

BioGPS Gene:25777 SUN2

COSMIC (genes):SUN2 SUN2

CTD Gene:25777 SUN2

dbSNP Gene:25777 SUN2

ENSEMBL:ENSG00000100242 SUN2

ENSEMBL_homo_sapiens_GENE:ENSG00000100242.16 SUN2

HGNC:14210 SUN2

KEGG Gene (Homo sapiens):25777 SUN2

Monarch:25777 SUN2

NCBI Gene:25777 SUN2

OMIM:613569 SUN2

UCSC:Q9UH99 SUN2

Reference Transcript

Other Identifiers

11744355_a_at

11744446_a_at

11748049_x_at

11749479_a_at

11752062_a_at

16935142

16935176

212144_PM_at

212144_at

25777

35336_at

3960823

3960825

3960826

3960828

3960829

3960834

3960835

3960836

3960837

3960838

3960839

3960842

3960843

3960845

3960847

3960850

3960851

3960852

3960853

3960854

3960857

3960858

3960859

3960866

3960869

3960870

3960895

8076137

A_32_P194115

GE766443

GO:0000228

GO:0000278

GO:0000781

GO:0000794

GO:0005515

GO:0005521

GO:0005634

GO:0005635

GO:0005637

GO:0005694

GO:0005768

GO:0007010

GO:0007018

GO:0007052

GO:0007097

GO:0008017

GO:0008092

GO:0010008

GO:0016020

GO:0021817

GO:0022414

GO:0030154

GO:0030335

GO:0031022

GO:0031410

GO:0031965

GO:0034993

GO:0042802

GO:0043226

GO:0043495

GO:0048856

GO:0048870

GO:0051321

GO:0051642

GO:0060090

GO:0090292

GO:0140444

HMNXSV003046346

Hs.5898.1.S1_3p_at

ILMN_2099301

PH_hs_0019297

TC22001495.hg

Participates

as a component of

Telomere Attachment Plate [nuclear envelope] (Homo sapiens)

as an input of

Telomeres cluster at the nuclear membrane (Homo sapiens)

Cross References

RefSeq

NP_001186508.1, NP_001186509.1, NP_056189.1

OpenTargets

ENSG00000100242

HPA

ENSG00000100242-SUN2

GeneCards

Q9UH99

Ensembl

ENST00000405018, ENST00000406622, ENSP00000508608, ENST00000689035, ENSP00000385616, ENST00000405510, ENSP00000383992, ENSP00000385740, ENSG00000100242

PRO

Q9UH99

Pharos - Targets

Q9UH99

PDB

4FI9, 6WME, 6WMD, 4DXR, 3UNP, 4DXS, 4DXT, 6WMG, 6WMF

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WXH0 SYNE2	1	SYNE2 [nuclear envelope] (R-HSA-912404)	0.85	11
UniProt:Q8NF91 SYNE1	1	SYNE1 [nuclear envelope] (R-HSA-912352)	0.807	7
UniProt:P20339 RAB5A	7	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [cytosol] (R-HSA-8870432) RAB5A [early endosome membrane] (R-HSA-2130175) RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257)	0.798	6
UniProt:P51148 RAB5C	10	RAB5C [azurophil granule membrane] (R-HSA-6799338) RAB5C [plasma membrane] (R-HSA-6806265) GGC-RAB5C [macropinosome membrane] (R-HSA-9837694) RAB5C [cytosol] (R-HSA-8870413) GGC-RAB5C [cytosol] (R-HSA-8870436) GGC-RAB5C [early endosome membrane] (R-HSA-8875331) RAB5C [early endosome membrane] (R-HSA-8854157) RAB5C [cytoplasmic vesicle membrane] (R-HSA-434198) RAB5C [Golgi membrane] (R-HSA-434334) GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (R-HSA-8871129)	0.744	5
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.723	5
UniProt:Q8N205 SYNE4			0.71	4
UniProt:Q8N6L0 KASH5			0.683	3
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.683	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.669	4
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.659	3
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.641	4
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.564	4
UniProt:P53618 COPB1	8	COPB1 [endoplasmic reticulum membrane] (R-HSA-6810955) COPB1 [ficolin-1-rich granule membrane] (R-HSA-6800972) COPB1 [tertiary granule membrane] (R-HSA-6800175) COPB1 [plasma membrane] (R-HSA-6806431) COPB1 [secretory granule membrane] (R-HSA-6800914) COPB1 [transport vesicle] (R-HSA-6808736) COPB1 [Golgi membrane] (R-HSA-6808735) COPB1 [cytosol] (R-HSA-199995)	0.564	3
UniProt:Q6ZMZ3 SYNE3			0.558	2
UniProt:Q8IXM6 NRM			0.556	3
UniProt:Q9NZM5 NOP53			0.527	2
UniProt:Q8N6G5 CSGALNACT2	1	CSGALNACT2 [Golgi membrane] (R-HSA-1971506)	0.527	3
UniProt:P56539 CAV3	1	CAV3 [plasma membrane] (R-HSA-1368135)	0.527	2
UniProt:P50579 METAP2	1	METAP2 [cytosol] (R-HSA-2534094)	0.527	2
UniProt:Q8TBX8 PIP4K2C	2	PIP4K2C [nucleoplasm] (R-HSA-6811499) PIP4K2C [cytosol] (R-HSA-1604638)	0.527	3
UniProt:Q8WWF5 ZNRF4			0.527	2
UniProt:Q2TAP0 GOG7B			0.527	2
UniProt:Q9BTZ2 DHRS4	3	DHRS4 [endoplasmic reticulum membrane] (R-HSA-2980897) DHRS4 [peroxisomal matrix] (R-HSA-9033097) DHRS4 [cytosol] (R-HSA-9033122)	0.527	4
UniProt:Q9H9Q2 COPS7B	2	COPS7B [cytosol] (R-HSA-416966) COPS7B [nucleoplasm] (R-HSA-5697023)	0.527	2
UniProt:Q9UKA2 FBXL4	1	FBXL4 [cytosol] (R-HSA-8850899)	0.527	2
UniProt:P16219 ACADS	1	ACADS [mitochondrial matrix] (R-HSA-49493)	0.527	2
UniProt:P48426 PIP4K2A	2	PIP4K2A [nucleoplasm] (R-HSA-6811484) PIP4K2A [cytosol] (R-HSA-1604641)	0.527	3
UniProt:P78356 PIP4K2B	3	p-S326-PIP4K2B [nucleoplasm] (R-HSA-8877679) PIP4K2B [nucleoplasm] (R-HSA-6811503) PIP4K2B [cytosol] (R-HSA-1806208)	0.527	3
UniProt:A5A3E0 POTEF			0.527	2
UniProt:Q9NWM8 FKBP14 gene	1	FKBP14 [endoplasmic reticulum lumen] (R-HSA-535607)	0.527	3
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003)	0.527	2
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.527	3
UniProt:Q8WXH0-1 SYNE2			0.524	2
UniProt:Q8NF91-1 SYNE1			0.524	2
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.499	3

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