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PPIE [nucleoplasm]
Stable Identifier
R-HSA-6781959
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Peptidyl-prolyl cis-trans isomerase E, Cyclophilin-33, CYP33, Rotamase E
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
ERCC5 and RPA bind TC-NER site (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
PPIE [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UNP9 PPIE
Gene Names
PPIE, CYP33
Chain
chain:1-301
Reference Genes
BioGPS Gene:10450 PPIE
COSMIC (genes):PPIE PPIE
CTD Gene:10450 PPIE
dbSNP Gene:10450 PPIE
ENSEMBL:ENSG00000084072 PPIE
ENSEMBL_homo_sapiens_GENE:ENSG00000084072.17 PPIE
HGNC:9258 PPIE
KEGG Gene (Homo sapiens):10450 PPIE
Monarch:10450 PPIE
NCBI Gene:10450 PPIE
OMIM:602435 PPIE
UCSC:Q9UNP9 PPIE
Reference Transcript
RefSeq:NM_006112.3 PPIE
RefSeq:XM_017000051.1 PPIE
RefSeq:NM_001195007.1 PPIE
RefSeq:NM_203456.2 PPIE
Other Identifiers
10450
11716896_a_at
11716897_x_at
11739533_a_at
11740033_a_at
11753960_x_at
16662908
202494_PM_at
202494_at
210502_PM_s_at
210502_s_at
229375_PM_at
229375_at
2331616
2331619
2331620
2331624
2331625
2331626
2331627
2331630
2331633
2331635
2331636
2331637
2331638
2331639
2331640
2331645
2331647
2331648
2407904
2407921
34364_at
34365_at
34366_g_at
63583_at
7900354
A_14_P200019
A_23_P74526
A_24_P54083
GE54371
GO:0000398
GO:0000413
GO:0003676
GO:0003723
GO:0003729
GO:0003755
GO:0003824
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005681
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006397
GO:0006457
GO:0008143
GO:0008380
GO:0016018
GO:0016071
GO:0016607
GO:0016853
GO:0031410
GO:0034774
GO:0036211
GO:0043226
GO:0043231
GO:0045070
GO:0071007
GO:0071013
GO:0140096
GO:1904813
HMNXSV003020194
HMNXSV003020445
HMNXSV003057383
Hs.22516.0.A1_3p_at
ILMN_1674825
ILMN_1680341
ILMN_2326737
ILMN_2348503
PH_hs_0022035
TC01004332.hg
g2828150_3p_a_at
g2828150_3p_x_at
g5174636_3p_at
p33345
Participates
as a component of
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PPIE [secretory granule lumen]
PPIE [extracellular region]
PPIE [ficolin-1-rich granule lumen]
Inferred To
Ghost homologue of PPIE [nucleoplasm]
(Bos taurus)
Ghost homologue of PPIE [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of PPIE [nucleoplasm]
(Canis familiaris)
Ghost homologue of PPIE [nucleoplasm]
(Danio rerio)
Ghost homologue of PPIE [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of PPIE [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of PPIE [nucleoplasm]
(Gallus gallus)
Ghost homologue of PPIE [nucleoplasm]
(Mus musculus)
Ghost homologue of PPIE [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of PPIE [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of PPIE [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of PPIE [nucleoplasm]
(Schizosaccharomyces pombe)
Ghost homologue of PPIE [nucleoplasm]
(Sus scrofa)
Ghost homologue of PPIE [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001181936.1
,
NP_006103.1
,
NP_982281.1
,
XP_016855540.1
OpenTargets
ENSG00000084072
IntEnz
5.2.1.8
HPA
ENSG00000084072-PPIE
GeneCards
Q9UNP9
Ensembl
ENST00000324379
,
ENST00000372830
,
ENSP00000348904
,
ENSP00000361918
,
ENSP00000312769
,
ENST00000356511
,
ENSG00000084072
PRO
Q9UNP9
Pharos - Targets
Q9UNP9
PDB
5YZG
,
2KU7
,
3MDF
,
2CQB
,
7W5A
,
5Z56
,
8CH6
,
7W5B
,
5Z57
,
5MQF
,
7ZEV
,
7A5P
,
7ZEW
,
2KYX
,
6FF7
,
8C6J
,
7ZEX
,
3UCH
,
7W59
,
7ABI
,
6ID0
,
7ZEY
,
2R99
,
3LPY
,
1ZMF
,
6ID1
,
6ICZ
,
7ZEZ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.704
4
UniProt:Q9CSN1 Snw1
1
Snw1 [nucleoplasm]
(R-MMU-2065315)
0.564
2
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
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