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PSIP1 [cytosol]
Stable Identifier
R-HSA-3008840
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PC4 and SFRS1-interacting protein, PSIP1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Integration of provirus (Homo sapiens)
Formation of Pre-Integration Complex (PIC) (Homo sapiens)
PIC (PreIntegration Complex) [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
Import of PIC to the Host Nucleus (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
Vpr:importin-alpha complex [cytosol] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
Integrase binds viral DNA ends (Homo sapiens)
PIC (PreIntegration Complex) [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
viral DNA bound with Integrase in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
Terminal (3' end) cleavage of viral DNA (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
viral DNA bound with Integrase in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
APOBEC3G mediated resistance to HIV-1 infection (Homo sapiens)
Association of APOBEC3G with Gag (Homo sapiens)
APOBEC3G:HIV-1PIC [cytosol] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
Interactions of Vpr with host cellular proteins (Homo sapiens)
Vpr-mediated nuclear import of PICs (Homo sapiens)
Interaction of Vpr with importin alpha (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
Vpr:importin-alpha complex [cytosol] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
Vpr binds nucleoporins (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
PIC anchored to the NPC [nuclear envelope] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
PSIP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75475 PSIP1
Gene Names
PSIP1, DFS70, LEDGF, PSIP2
Chain
chain:1-530
Reference Genes
BioGPS Gene:11168 PSIP1
COSMIC (genes):PSIP1 PSIP1
CTD Gene:11168 PSIP1
dbSNP Gene:11168 PSIP1
ENSEMBL:ENSG00000164985 PSIP1
HGNC:9527 PSIP1
KEGG:hsa:11168 PSIP1
Monarch:11168 PSIP1
NCBI Gene:11168 PSIP1
OMIM:603620 PSIP1
UCSC:O75475 PSIP1
Reference Transcript
RefSeq:NM_021144.3 PSIP1
RefSeq:NM_001317900.1 PSIP1
RefSeq:NM_001128217.2 PSIP1
RefSeq:NM_001317898.1 PSIP1
RefSeq:NM_033222.4 PSIP1
Other Identifiers
11168
11734600_a_at
11742933_a_at
11761869_at
1554933_PM_at
1554933_at
17092615
205961_PM_s_at
205961_s_at
209337_PM_at
209337_at
210758_PM_at
210758_at
3163066
3199789
3199791
3199792
3199793
3199796
3199798
3199799
3199800
3199801
3199802
3199803
3199804
3199805
3199806
3199807
3199808
3199809
3199810
3199812
3199814
3199815
3199816
3199817
3199818
3199820
3199822
3199823
3199824
3199825
3199826
3199827
3199828
37622_r_at
39243_s_at
70817_r_at
8160238
8180299
A_23_P256384
A_24_P929106
A_24_P98371
A_32_P22702
A_32_P32043
A_33_P3226605
A_33_P3226610
GE54580
GO:0000395
GO:0000791
GO:0000792
GO:0003677
GO:0003682
GO:0003713
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0006325
GO:0006338
GO:0006355
GO:0006979
GO:0009408
GO:0034399
GO:0043226
GO:0045944
GO:0060090
GO:0065003
GO:0097100
GO:0140110
GO:0140297
HMNXSV003010046
HMNXSV003042644
Hs2.375073.1.S1_3p_x_at
ILMN_1679319
ILMN_1788701
PH_hs_0023938
TC09000925.hg
U94319_at
g3283351_3p_at
g4050033_3p_at
g4758869_3p_s_at
Participates
as an input of
Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 (Homo sapiens)
as a component of
RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 [cytosol] (Homo sapiens)
viral DNA bound with Integrase in PIC [cytosol] (Homo sapiens)
PIC (PreIntegration Complex) [cytosol] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
Other forms of this molecule
PSIP1 [nucleoplasm]
Cross References
OpenTargets
ENSG00000164985
ENSEMBL
ENST00000380716
,
ENST00000380738
,
ENST00000397519
,
ENST00000380733
,
ENSP00000380653
,
ENST00000380715
,
ENSP00000370114
,
ENSP00000370109
,
ENSP00000370092
,
ENSP00000370091
HPA
ENSG00000164985-PSIP1
PRO
O75475
Pharos - Targets
O75475
GlyGen
O75475
PDB
7PEL
,
2B4J
,
3ZEH
,
6EMP
,
3F9K
,
6EMQ
,
5N88
,
3HPG
,
8PC5
,
8PC6
,
1Z9E
,
6EMO
,
8PEO
,
7OUG
,
2M16
,
6ZV0
,
3HPH
,
8PEP
,
7OUF
,
2MSR
,
3U88
,
6EMR
,
2MTN
,
5YI9
,
6TVM
,
4FU6
,
8CBQ
,
5OYM
,
7OUH
,
2N3A
,
7Z1Z
,
6S01
,
8CBN
,
6TRJ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99708 RBBP8
4
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
RBBP8 [nucleoplasm]
(R-HSA-912399)
Ac-K-RBBP8 [nucleoplasm]
(R-HSA-5685955)
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
0.602
4
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.544
2
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