Reactome | PAF1 [nucleoplasm]

PAF1 [nucleoplasm]

Stable Identifier

R-HSA-8866689

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RNA polymerase II-associated factor 1 homolog, PAF1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8N7H5 PAF1

Gene Names

PAF1, PD2

Chain

chain:1-531

Reference Genes

BioGPS Gene:54623 PAF1

COSMIC (genes):PAF1 PAF1

CTD Gene:54623 PAF1

dbSNP Gene:54623 PAF1

ENSEMBL:ENSG00000006712 PAF1

HGNC:25459 PAF1

KEGG:hsa:54623 PAF1

Monarch:54623 PAF1

NCBI Gene:54623 PAF1

OMIM:610506 PAF1

UCSC:Q8N7H5 PAF1

Reference Transcript

Other Identifiers

11744204_a_at

11749516_a_at

16872203

202093_PM_s_at

202093_s_at

31866_at

3861979

3861980

3861981

3861982

3861983

3861984

3861985

3861986

3861987

3861988

3861989

3861990

3861991

3861992

3861993

3861994

3861995

3861996

3861997

3861998

3861999

3862000

3862001

3862002

3862003

54623

8036720

A_23_P142272

A_24_P216087

GE55976

GO:0000122

GO:0000993

GO:0001650

GO:0001711

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006355

GO:0006368

GO:0016020

GO:0016055

GO:0016071

GO:0016593

GO:0019827

GO:0031124

GO:0034504

GO:0043226

GO:0043231

GO:0045638

GO:0045944

GO:0071222

GO:1902808

HMNXSV003048607

ILMN_1669508

PH_hs_0009194

TC19001518.hg

g9506582_3p_a_at

Participates

as a component of

PAF1C [nucleoplasm] (Homo sapiens)

Inferred To

PAF1 [nucleoplasm] (Bos taurus)

PAF1 [nucleoplasm] (Canis familiaris)

PAF1 [nucleoplasm] (Gallus gallus)

PAF1 [nucleoplasm] (Saccharomyces cerevisiae)

PAF1 [nucleoplasm] (Schizosaccharomyces pombe)

PAF1 [nucleoplasm] (Sus scrofa)

Paf1 [nucleoplasm] (Mus musculus)

Paf1 [nucleoplasm] (Rattus norvegicus)

paf1 [nucleoplasm] (Danio rerio)

paf1 [nucleoplasm] (Dictyostelium discoideum)

paf1 [nucleoplasm] (Xenopus tropicalis)

pafo-1 [nucleoplasm] (Caenorhabditis elegans)

atms [nucleoplasm] (Drosophila melanogaster)

Cross References

ENSEMBL

ENST00000221265, ENSP00000468874, ENST00000595564, ENSP00000221265

OpenTargets

ENSG00000006712

HPA

ENSG00000006712-PAF1

PRO

Q8N7H5

Pharos - Targets

Q8N7H5

GlyGen

Q8N7H5

PDB

7OPD, 5ZYQ, 4M6T, 7UNC, 7OOP, 7UND, 7OPC, 6TED, 6GMH

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.959	33
UniProt:Q8WVC0 LEO1	1	LEO1 [nucleoplasm] (R-HSA-3322361)	0.949	30
UniProt:P23193 TCEA1	1	TCEA1 [nucleoplasm] (R-HSA-65748)	0.577	4
UniProt:P61218 POLR2F	2	POLR2F [cytosol] (R-HSA-1964441) POLR2F [nucleoplasm] (R-HSA-83714)	0.527	2
UniProt:Q8WY64 MYLIP	1	MYLIP [cytosol] (R-HSA-8850908)	0.527	2
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	3
UniProt:P56559 ARL4C	1	ARL4C [plasma membrane] (R-HSA-9618406)	0.527	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	2
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.499	4