Reactome | PPIE [secretory granule lumen]

PPIE [secretory granule lumen]

Stable Identifier

R-HSA-6801369

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Peptidyl-prolyl cis-trans isomerase E, Cyclophilin-33, CYP33, Rotamase E

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UNP9 PPIE

Gene Names

PPIE, CYP33

Chain

chain:1-301

Reference Genes

BioGPS Gene:10450 PPIE

COSMIC (genes):PPIE PPIE

CTD Gene:10450 PPIE

dbSNP Gene:10450 PPIE

ENSEMBL:ENSG00000084072 PPIE

HGNC:9258 PPIE

KEGG Gene (Homo sapiens):10450 PPIE

Monarch:10450 PPIE

NCBI Gene:10450 PPIE

OMIM:602435 PPIE

UCSC:Q9UNP9 PPIE

Reference Transcript

Other Identifiers

0004610632

10450

11716896_a_at

11716897_x_at

11739533_a_at

11740033_a_at

11753960_x_at

16662908

202494_PM_at

202494_at

210502_PM_s_at

210502_s_at

229375_PM_at

229375_at

2331616

2331619

2331620

2331624

2331625

2331626

2331627

2331630

2331633

2331635

2331636

2331637

2331638

2331639

2331640

2331645

2331647

2331648

2407904

2407921

34364_at

34365_at

34366_g_at

63583_at

7900354

A_14_P200019

A_23_P74526

A_24_P54083

GE54371

GO:0000398

GO:0000413

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0003755

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006355

GO:0006397

GO:0006457

GO:0006464

GO:0008143

GO:0008150

GO:0008380

GO:0009058

GO:0016018

GO:0016607

GO:0016853

GO:0031410

GO:0032991

GO:0034641

GO:0034774

GO:0043226

GO:0045070

GO:0071007

GO:0071013

GO:1904813

HMNXSV003020194

HMNXSV003020445

HMNXSV003057383

Hs.22516.0.A1_3p_at

ILMN_1654037

ILMN_1674825

ILMN_1680341

ILMN_2326737

ILMN_2348503

PH_hs_0022035

TC01004332.hg

g2828150_3p_a_at

g2828150_3p_x_at

g5174636_3p_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

PPIE [extracellular region]

PPIE [ficolin-1-rich granule lumen]

PPIE [nucleoplasm]

Inferred To

cyp33 [secretory granule lumen] (Drosophila melanogaster)

PPIE [secretory granule lumen] (Bos taurus)

PPIE [secretory granule lumen] (Canis familiaris)

PPIE [secretory granule lumen] (Gallus gallus)

PPIE [secretory granule lumen] (Plasmodium falciparum)

PPIE [secretory granule lumen] (Sus scrofa)

Ppie [secretory granule lumen] (Mus musculus)

Ppie [secretory granule lumen] (Rattus norvegicus)

ppie [secretory granule lumen] (Danio rerio)

ppie [secretory granule lumen] (Xenopus tropicalis)

cyn-13 [secretory granule lumen] (Caenorhabditis elegans)

wis2 [secretory granule lumen] (Schizosaccharomyces pombe)

CPR6 [secretory granule lumen] (Saccharomyces cerevisiae)

Homologues of PPIE [secretory granule lumen] (Plasmodium falciparum)

ppiA [secretory granule lumen] (Dictyostelium discoideum)

Cross References

RefSeq

NP_982281.1, NP_001181936.1, NP_006103.1, XP_016855540.1

OpenTargets

ENSG00000084072

GeneCards

Q9UNP9

HPA

ENSG00000084072-PPIE

Ensembl

ENSP00000361918, ENSP00000312769, ENSG00000084072, ENSP00000348904, ENST00000324379, ENST00000356511, ENST00000372830

PRO

Q9UNP9

Pharos - Targets

Q9UNP9

PDB

5Z57, 3LPY, 3UCH, 2CQB, 6ID1, 5MQF, 2KYX, 5Z56, 2R99, 7A5P, 2KU7, 6FF7, 5YZG, 7ABI, 6ID0, 1ZMF, 3MDF, 6ICZ

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.882	12
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.739	9
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.704	4
UniProt:Q9CSN1 Snw1	1	Snw1 [nucleoplasm] (R-MMU-2065315)	0.564	2
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P68431 H3C1	20	HIST1H3A [extracellular region] (R-HSA-977570) 2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288)	0.544	3
UniProt:Q83D60 Q83D60			0.488	2

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