Reactome | NDUFB7 [mitochondrial inner membrane]

NDUFB7 [mitochondrial inner membrane]

Stable Identifier

R-HSA-59940

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase B18 subunit , Complex I-B18, CI-B18, Cell adhesion protein SQM1

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB7 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17568 NDUFB7

Gene Names

NDUFB7

Chain

initiator methionine:1, chain:2-137

Reference Genes

BioGPS Gene:4713 NDUFB7

COSMIC (genes):NDUFB7 NDUFB7

CTD Gene:4713 NDUFB7

dbSNP Gene:4713 NDUFB7

ENSEMBL:ENSG00000099795 NDUFB7

ENSEMBL_homo_sapiens_GENE:ENSG00000099795 NDUFB7

HGNC:7702 NDUFB7

KEGG Gene (Homo sapiens):4713 NDUFB7

Monarch:4713 NDUFB7

NCBI Gene:4713 NDUFB7

OMIM:603842 NDUFB7

UCSC:P17568 NDUFB7

Reference Transcript

RefSeq:NM_004146.5 NDUFB7

Other Identifiers

0007100039

11718991_a_at

16869660

202839_s_at

2817

35773_i_at

35774_r_at

3852824

3852825

3852827

3852828

3852829

4713

5XTC

5XTD

5XTH

5XTI

8034843

A_23_P50872

AAA35675

AAF17188

AAF91223

AAH02595

AF112200

AF217091

BC002595

CAG29350

CCDS12314

CH471106

CR450354

EAW84436

ENSG00000099795

ENSP00000215565

ENST00000215565

EntrezGene:4713

g10764846_3p_at

g10764846_3p_x_at

GO:0003674

GO:0003954

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0005758

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0008150

GO:0016020

GO:0016491

GO:0022607

GO:0032981

GO:0032991

GO:0034641

GO:0043226

GO:0044281

GO:0055114

GO:0065003

GO:0070469

HGNC:7702

HPA002817

IPR008698

M0R3B8

M33374

MIM:603842

NDUFB7

NDUFB7-201

NM_004146

NP_004137

PF05676

TC19001240.hg

uc002mzg.4

UPI000013C68C

XM_011528039

XP_011526341

Participant Of

hasComponent

HP subcomplex [mitochondrial inner membrane]

Inferred To

Ghost homologue of NDUFB7 [mitochondrial inner membrane] (Taeniopygia guttata)

NDUFB7 [mitochondrial inner membrane] (Bos taurus)

NDUFB7 [mitochondrial inner membrane] (Canis familiaris)

NDUFB7 [mitochondrial inner membrane] (Danio rerio)

NDUFB7 [mitochondrial inner membrane] (Drosophila melanogaster)

NDUFB7 [mitochondrial inner membrane] (Gallus gallus)

NDUFB7 [mitochondrial inner membrane] (Mus musculus)

NDUFB7 [mitochondrial inner membrane] (Rattus norvegicus)

NDUFB7 [mitochondrial inner membrane] (Sus scrofa)

NDUFB7 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_004137.2

OpenTargets

ENSG00000099795

GeneCards

P17568

PRO

P17568

Orphanet

24748

PDB

5XTI, 5XTC, 5XTD, 5XTH

HMDB Protein

HMDBP00173

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.488	2