NPAS4 stimulates GEM gene expression

Stable Identifier
R-HSA-9769014
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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NPAS4 stimulates GEM gene expression
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Based on a study in rat primary neurons, NPAS4 significantly upregulates GEM gene transcription (Brigidi et al. 2019). In a mouse model system, Gem gene was also identified as an Npas4 target gene which is induced by Npas4 and promotes neuroprotection after ischemic brain injury (Takahashi et al. 2021). GEM is also induced in human cerebral organoids cultured under ischemic conditions (Takahashi et al. 2021).
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Output
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as an event of
This event is regulated
Positively by
Regulator
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):GEM gene [nucleoplasm] (Homo sapiens)
Active Unit
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2) [nucleoplasm]
Inferred From
Npas4 stimulates Gem gene expression (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-15)
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