Reactome | GADD45GIP1 [mitochondrial matrix]

GADD45GIP1 [mitochondrial matrix]

Stable Identifier

R-HSA-5368253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Growth arrest and DNA damage-inducible proteins-interacting protein 1, G45IP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TAE8 GADD45GIP1

Gene Names

GADD45GIP1, MRPL59, PLINP1, PRG6

Chain

chain:1-222

Reference Genes

BioGPS Gene:90480 GADD45GIP1

COSMIC (genes):GADD45GIP1 GADD45GIP1

CTD Gene:90480 GADD45GIP1

dbSNP Gene:90480 GADD45GIP1

ENSEMBL:ENSG00000179271 GADD45GIP1

ENSEMBL_homo_sapiens_GENE:ENSG00000179271.3 GADD45GIP1

HGNC:29996 GADD45GIP1

KEGG Gene (Homo sapiens):90480 GADD45GIP1

Monarch:90480 GADD45GIP1

NCBI Gene:90480 GADD45GIP1

OMIM:605162 GADD45GIP1

UCSC:Q8TAE8 GADD45GIP1

Reference Transcript

RefSeq:NM_052850.3 GADD45GIP1

Other Identifiers

11719082_a_at

16869387

212891_PM_s_at

212891_s_at

3851912

3851913

3851914

3851915

3851916

3851917

3851918

3851919

3851920

8034605

90480

A_23_P39019

A_33_P3273148

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005759

GO:0005762

GO:0005840

GO:0007049

GO:0032543

GO:0043226

GO:0140053

GO:1990904

Hs.83135.1.A1_3p_a_at

ILMN_1751530

PH_hs_0027173

TC19001216.hg

Participates

as a component of

39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)

Inferred To

CRIF [mitochondrial matrix] (Drosophila melanogaster)

Ghost homologue of GADD45GIP1 [mitochondrial matrix] (Danio rerio)

Ghost homologue of GADD45GIP1 [mitochondrial matrix] (Gallus gallus)

GADD45GIP1 [mitochondrial matrix] (Bos taurus)

GADD45GIP1 [mitochondrial matrix] (Caenorhabditis elegans)

GADD45GIP1 [mitochondrial matrix] (Canis familiaris)

GADD45GIP1 [mitochondrial matrix] (Sus scrofa)

Gadd45gip1 [mitochondrial matrix] (Mus musculus)

Gadd45gip1 [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_443082.2

OpenTargets

ENSG00000179271

HPA

ENSG00000179271-GADD45GIP1

GeneCards

Q8TAE8

Ensembl

ENSP00000323065, ENST00000316939, ENSG00000179271

PRO

Q8TAE8

Pharos - Targets

Q8TAE8

PDB

7OID, 6ZSD, 6VMI, 7OF7, 7ODR, 7OF6, 7OIC, 6ZSE, 7QI5, 7A5G, 6NU3, 7OF5, 7QI4, 6NU2, 6ZSC, 7OIB, 5OOL, 7A5I, 3J9M, 7O9M, 7ODT, 6VLZ, 7O9K, 7QI6, 7OIE, 7ODS, 7PO4, 7OF0, 7QH6, 7OI8, 7OI7, 6ZM6, 7A5K, 7A5F, 6ZM5, 7OI6, 7PD3, 7OG4, 8OIT, 7OIA, 7OF4, 8ANY, 6ZSA, 6ZSB, 7A5J, 7OF3, 6I9R, 8OIR, 3J7Y, 5OOM, 7OI9, 7A5H, 6ZSG, 6ZS9, 7L20, 7L08, 7QH7, 7OF2

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.635	4
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.593	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P42227 Stat3	13	phospho-Stat3 [nucleoplasm] (R-MMU-1112554) phospho-Stat3 [cytosol] (R-MMU-914048) Stat3 [cytosol] (R-MMU-539044) phospho-Stat3 [cytosol] (R-MMU-8983130) Stat3 [cytosol] (R-MMU-914084) p-Y705-Stat3 [cytosol] (R-MMU-914034) p(Y705)-Stat3 [nucleoplasm] (R-MMU-2730582) phospho-Stat3 [cytosol] (R-MMU-539048) phospho-Stat3 [nucleoplasm] (R-MMU-9027589) phospho-Stat3 [nucleoplasm] (R-MMU-9701429) phospho-Stat3 [nucleoplasm] (R-MMU-9701435) phospho-Stat3 [cytosol] (R-MMU-8982823) phospho-Stat3 [nucleoplasm] (R-MMU-8983188)	0.463	3