Reactome | SORBS3 [cytosol]

SORBS3 [cytosol]

Stable Identifier

R-HSA-445805

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Vinexin, VINEX_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60504 SORBS3

Gene Names

SORBS3, SCAM1

Chain

chain:1-671

Reference Genes

BioGPS Gene:10174 SORBS3

COSMIC (genes):SORBS3 SORBS3

CTD Gene:10174 SORBS3

dbSNP Gene:10174 SORBS3

ENSEMBL:ENSG00000120896 SORBS3

ENSEMBL_homo_sapiens_GENE:ENSG00000120896 SORBS3

HGNC:30907 SORBS3

KEGG Gene (Homo sapiens):10174 SORBS3

Monarch:10174 SORBS3

NCBI Gene:10174 SORBS3

OMIM:610795 SORBS3

UCSC:O60504 SORBS3

Reference Transcript

Other Identifiers

0003850324

10174

11716773_s_at

11734781_a_at

11747575_a_at

11753099_a_at

15849

17066650

207788_s_at

209253_at

2CT3

2DLM

2NWM

2YUP

3089484

3089487

3089488

3089489

3089490

3089491

3089493

3089495

3089498

3089500

3089501

3089502

3089505

3089506

3089507

3089511

3089512

3089514

3089516

3089517

3089518

3089520

3089521

3089523

3089524

3089528

3089529

3089530

3089531

3089532

35675_at

48034

8145151

A_14_P139103

A_23_P300714

A_33_P3409625

AAC09244

AAD32304

AAH10146

AAH67260

AAH91514

AC037459

AF037261

AF064807

BC010146

BC067260

BC091514

CCDS47824

CCDS6031

CH471080

E5RIA0

E5RJP2

E7EQH0

EAW63675

ENSG00000120896

ENSP00000240123

ENSP00000429764

ENST00000240123

ENST00000240123.11

ENST00000523965

ENST00000523965.5

EntrezGene:10174

g3004947_3p_at

g5032072_3p_a_at

GE54297

GO:0000122

GO:0003674

GO:0005198

GO:0005200

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005925

GO:0006936

GO:0007015

GO:0007155

GO:0008092

GO:0008134

GO:0017166

GO:0030054

GO:0031589

GO:0043226

GO:0043410

GO:0051495

GO:0051496

H0YB51

HGNC:30907

HPA015849

HPA048034

ILMN_1661641

ILMN_1673223

ILMN_1717904

ILMN_1789338

ILMN_2261099

IPR001452

IPR003127

IPR028510

IPR035607

IPR035608

IPR035609

IPR036028

MIM:610795

NM_001018003

NM_005775

NP_001018003

NP_005766

PF00018

PF02208

PF14604

PH_hs_0023606

PR00452

PR00499

SM00326

SM00459

SORBS3

SORBS3-201

SORBS3-221

TC08000173.hg

UPI000007328E

UPI00001AE6B5

XM_005273371

XM_006716266

XM_017012944

XM_017012945

XM_017012946

XP_005273428

XP_006716329

XP_016868433

XP_016868434

XP_016868435

Participant Of

hasComponent

integrin:cytoskeletal ahesion complex [plasma membrane]

Inferred To

Ghost homologue of SORBS3 [cytosol] (Caenorhabditis elegans)

SORBS3 [cytosol] (Bos taurus)

SORBS3 [cytosol] (Canis familiaris)

SORBS3 [cytosol] (Danio rerio)

SORBS3 [cytosol] (Mus musculus)

SORBS3 [cytosol] (Rattus norvegicus)

SORBS3 [cytosol] (Sus scrofa)

SORBS3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_005273428.1, NP_005766.3, NP_001018003.1, XP_016868434.1, XP_016868435.1, XP_016868433.1

OpenTargets

ENSG00000120896

GeneCards

O60504

PRO

O60504

HMDB Protein

HMDBP01932

PDB

2NWM, 2CT3, 2DLM, 2YUP

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13177 PAK2	11	PAK2 [cytosol] (R-HSA-211604) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946)	0.775	6
UniProt:P61978 HNRNPK	2	SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.666	4
UniProt:Q9BUJ2 HNRNPUL1	1	HNRNPUL1 [nucleoplasm] (R-HSA-72106)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9BST9 RTKN	1	RTKN [cytosol] (R-HSA-5666184)	0.508	3
UniProt:Q5ST30 VARS2	1	VARS2 [mitochondrial matrix] (R-HSA-379626)	0.488	2
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.488	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.488	2
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.488	2
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.488	2
UniProt:P47897 QARS	2	QARS [mitochondrial matrix] (R-HSA-379592) QARS [cytosol] (R-HSA-379615)	0.488	2
UniProt:P31751 AKT2	8	p-T309,S474-AKT2 [cytosol] (R-HSA-166800) p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056) p-T309-AKT2 [cytosol] (R-HSA-202066) p-T309,S474-AKT2 [nucleoplasm] (R-HSA-202087) AKT2 [cytosol] (R-HSA-49859) AKT2 [plasma membrane] (R-HSA-202053) p-S474-AKT2 [plasma membrane] (R-HSA-2317312) p-T309,S474-AKT2 [cytosol] (R-HSA-202062)	0.488	2
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.488	2
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.488	2
UniProt:O14964 HGS	1	HGS [cytosol] (R-HSA-182954)	0.488	2
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.488	2
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.488	2