Reactome | COG8 [Golgi membrane]

COG8 [Golgi membrane]

Stable Identifier

R-HSA-6808728

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96MW5 COG8

Gene Names

COG8

Chain

chain:1-612

Reference Genes

BioGPS Gene:84342 COG8

COSMIC (genes):COG8 COG8

CTD Gene:84342 COG8

dbSNP Gene:84342 COG8

ENSEMBL:ENSG00000272617 COG8

HGNC:18623 COG8

KEGG Gene (Homo sapiens):84342 COG8

Monarch:84342 COG8

NCBI Gene:84342 COG8

OMIM:606979 COG8

UCSC:Q96MW5 COG8

Reference Transcript

RefSeq:NM_032382.4 COG8

Other Identifiers

84342

A0A024R6Z6

AAH17492

AAI21023

AAI21024

BAB15301

BAB71157

COG8

COG8-207

EAW83266

EAW83267

ENSG00000213380

ENSP00000497669

ENST00000648169

EntrezGene:84342

GO:0000139

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005794

GO:0006810

GO:0006888

GO:0006891

GO:0008150

GO:0015031

GO:0016020

GO:0016192

GO:0017119

GO:0032588

GO:0032991

GO:0043226

H3BQV3

HGNC:18623

HPA041406

HPA049429

IPR007255

IPR016159

IPR016632

J3QRV3

MIM:606979

MIM:611182

NM_032382

NP_115758

PF04124

uc002ewy.3

UPI000013EBA1

Participant Of

hasComponent

COG complex [Golgi membrane]

Other forms of this molecule

COG8 [trans-Golgi network membrane]

Inferred To

COG8 [Golgi membrane] (Arabidopsis thaliana)

COG8 [Golgi membrane] (Bos taurus)

COG8 [Golgi membrane] (Caenorhabditis elegans)

COG8 [Golgi membrane] (Canis familiaris)

COG8 [Golgi membrane] (Danio rerio)

COG8 [Golgi membrane] (Dictyostelium discoideum)

COG8 [Golgi membrane] (Drosophila melanogaster)

COG8 [Golgi membrane] (Gallus gallus)

COG8 [Golgi membrane] (Mus musculus)

COG8 [Golgi membrane] (Oryza sativa)

COG8 [Golgi membrane] (Rattus norvegicus)

COG8 [Golgi membrane] (Sus scrofa)

COG8 [Golgi membrane] (Taeniopygia guttata)

COG8 [Golgi membrane] (Xenopus tropicalis)

Homologues of COG8 [Golgi membrane] (Arabidopsis thaliana)

Homologues of COG8 [Golgi membrane] (Sus scrofa)

Cross References

RefSeq

NP_115758.3

OpenTargets

ENSG00000213380

GeneCards

Q96MW5

PRO

Q96MW5

Orphanet

16432

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14964 HGS	1	HGS [cytosol] (R-HSA-182954)	0.556	3