Reactome | COG8 [Golgi membrane]

COG8 [Golgi membrane]

Stable Identifier

R-HSA-6808728

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG8 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96MW5 COG8

Gene Names

COG8

Chain

chain:1-612

Reference Genes

BioGPS Gene:84342 COG8

COSMIC (genes):COG8 COG8

CTD Gene:84342 COG8

dbSNP Gene:84342 COG8

ENSEMBL:ENSG00000213380.16 COG8

HGNC:18623 COG8

KEGG Gene (Homo sapiens):84342 COG8

Monarch:84342 COG8

NCBI Gene:84342 COG8

OMIM:606979 COG8

UCSC:Q96MW5 COG8

Reference Transcript

RefSeq:NM_032382.4 COG8

Other Identifiers

0007040138

11724303_a_at

11758480_s_at

16827645

219575_PM_s_at

219575_s_at

238863_3p_x_at

238863_PM_x_at

238863_x_at

3696526

3696527

3696528

3696529

3696530

3696531

3696540

3696541

3696542

3696544

3696546

3696547

3696548

3696550

52271_s_at

59958_at

76522_at

8002272

84342

84778_at

A_23_P218295

A_23_P37966

A_23_P502057

A_24_P155815

A_32_P92399

A_33_P3287379

GE62896

GO:0000139

GO:0000301

GO:0005515

GO:0005622

GO:0005737

GO:0005794

GO:0006891

GO:0007030

GO:0015031

GO:0016020

GO:0016192

GO:0017119

GO:0032588

GO:0032991

GO:0043226

GO:0070085

HMNXSV003052170

Hs.72322.0.A1_3p_at

Hs.72322.0.A1_3p_x_at

ILMN_1725246

ILMN_1829005

PH_hs_0007726

PH_hs_0031711

PH_hs_0038787

TC16001220.hg

g11641242_3p_s_at

Participates

as a component of

COG complex [Golgi membrane] (Homo sapiens)

Other forms of this molecule

COG8 [trans-Golgi network membrane]

Inferred To

COG8 [Golgi membrane] (Bos taurus)

COG8 [Golgi membrane] (Canis familiaris)

COG8 [Golgi membrane] (Danio rerio)

COG8 [Golgi membrane] (Gallus gallus)

COG8 [Golgi membrane] (Sus scrofa)

cog8 [Golgi membrane] (Dictyostelium discoideum)

cog8 [Golgi membrane] (Schizosaccharomyces pombe)

Cog8 [Golgi membrane] (Drosophila melanogaster)

Cog8 [Golgi membrane] (Mus musculus)

Cog8 [Golgi membrane] (Rattus norvegicus)

Ghost homologue of COG8 [Golgi membrane] (Xenopus tropicalis)

cogc-8 [Golgi membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_115758.3

OpenTargets

ENSG00000213380

HPA

ENSG00000213380-COG8

GeneCards

Q96MW5

Ensembl

ENSG00000213380, ENSP00000305459, ENST00000306875

PRO

Q96MW5

Pharos - Targets

Q96MW5

Orphanet

16432

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3

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