Reactome | K63polyUb-K30,K401-IKBKE [cytosol]

K63polyUb-K30,K401-IKBKE [cytosol]

Stable Identifier

R-MMU-9730436

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q9R0T8

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Mus musculus)
        
        Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Mus musculus)
        
        IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Mus musculus)
        
        K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Mus musculus)
        
        K63polyUb-K30,K401-IKBKE [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9R0T8

Reference Genes

BioGPS Gene:56489

ENSEMBL:ENSMUSG00000042349

KEGG:mmu:56489

Monarch:56489

NCBI Gene:56489

UCSC:Q9R0T8

Reference Transcript

Other Identifiers

10357604

1417813_at

17226771

4386654

4409338

4425951

4427399

4478878

4527339

4528341

4558277

4572492

4612783

4614471

4652596

4656831

4700655

4704692

4718944

4725073

4733142

4787002

4801638

4923794

4958346

4965250

4996300

5101495

5110833

5112494

5122513

5185881

5187479

5197110

5241698

5246875

5279749

5316326

5320607

5324641

5350527

5357638

5413434

5428697

5442644

5469118

5505774

5549040

5582399

56489

92301_at

A_51_P222280

GE37507

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0006468

GO:0006955

GO:0006974

GO:0008384

GO:0008630

GO:0010467

GO:0010628

GO:0010884

GO:0016605

GO:0016740

GO:0031625

GO:0031966

GO:0032481

GO:0034340

GO:0035456

GO:0036435

GO:0042802

GO:0043123

GO:0043226

GO:0043254

GO:0048255

GO:0060340

GO:0097400

GO:0098586

GO:0140096

ILMN_3161543

mMC024671

Participates

as a component of

K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Mus musculus)

Other forms of this molecule

phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]

phospho-p-S172-IKBKE [nucleoplasm]

phospho-p-S172-IKBKE [cytosol]

IKBKE [cytosol]

Inferred From

K63polyUb-K30,K401-IKBKE [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 30 (in Homo sapiens)

Coordinate

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 401 (in Homo sapiens)

Coordinate

401

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

ENSEMBL

ENSMUST00000062108, ENSMUSP00000054126, ENSMUSG00000042349

PRO

Q9R0T8

MGI

1929612

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N7N6 CIKS			0.499	3