Reactome | K63polyUb-K30,K401-IKBKE homodimer [cytosol]

K63polyUb-K30,K401-IKBKE homodimer [cytosol]

Stable Identifier

R-HSA-9730429

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

K63polyUb-K30,K401-TBK1:K63polyUb-K30,K401-IKBKE

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
        
        Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation (Homo sapiens)
        
        IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex (Homo sapiens)
        
        K63pUb-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
        
        K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
        
        Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Homo sapiens)
        
        IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Homo sapiens)
        
        K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
        
        K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Homo sapiens)

Participants

components

x 2 K63polyUb-K30,K401-IKBKE [cytosol] (Homo sapiens)

Participates

as a component of

Inferred To

K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Bos taurus)

K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Canis familiaris)

K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Gallus gallus)

K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Mus musculus)

K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Rattus norvegicus)

K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Sus scrofa)

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