Reactome | SETD2 [nucleoplasm]

SETD2 [nucleoplasm]

Stable Identifier

R-HSA-1183220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase SETD2, SETD2_HUMAN, KMT3A

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9BYW2 SETD2

Gene Names

SETD2, HIF1, HYPB, KIAA1732, KMT3A, SET2, HSPC069

Chain

chain:1-2564

Reference Genes

BioGPS Gene:29072 SETD2

COSMIC (genes):SETD2 SETD2

CTD Gene:29072 SETD2

dbSNP Gene:29072 SETD2

ENSEMBL:ENSG00000181555 SETD2

HGNC:18420 SETD2

Monarch:29072 SETD2

NCBI Gene:29072 SETD2

OMIM:612778 SETD2

UCSC:Q9BYW2 SETD2

Reference Transcript

RefSeq:NM_014159.6 SETD2

Other Identifiers

11716192_a_at

11716193_s_at

11716194_a_at

16953052

212493_PM_s_at

212493_s_at

215038_PM_s_at

215038_s_at

220946_PM_s_at

220946_s_at

241458_PM_at

241458_at

2672533

2672534

2672536

2672539

2672544

2672546

2672547

2672548

2672549

2672552

2672553

2672554

2672555

2672557

2672559

2672561

2672562

2672563

2672564

2672565

2672566

2672567

2672568

2672570

2672571

2672572

2672574

2672575

2672578

2672579

2672580

2672582

2672583

2672585

2672586

2672587

2672588

2672589

2672590

2672591

2672605

2672606

29072

35815_at

52661_at

72506_at

8086706

A_23_P21219

A_23_P44760

A_24_P187787

GE62720

GE84448

GO:0001525

GO:0001570

GO:0001763

GO:0001843

GO:0002376

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006281

GO:0006298

GO:0006325

GO:0006338

GO:0006355

GO:0006368

GO:0007010

GO:0008092

GO:0008168

GO:0010038

GO:0010468

GO:0010508

GO:0010569

GO:0010793

GO:0014070

GO:0016279

GO:0016740

GO:0018023

GO:0030154

GO:0030900

GO:0032259

GO:0032465

GO:0032727

GO:0034340

GO:0034728

GO:0035441

GO:0035987

GO:0042054

GO:0043014

GO:0043226

GO:0043279

GO:0045087

GO:0045778

GO:0046872

GO:0046975

GO:0048332

GO:0048568

GO:0048701

GO:0048856

GO:0048863

GO:0048864

GO:0048870

GO:0051607

GO:0060039

GO:0060669

GO:0060977

GO:0098542

GO:0140096

GO:0140938

GO:0140955

GO:1902850

GO:1905634

HMNXSV003010868

HMNXSV003058036

Hs.295848.0.A1_3p_at

Hs.306184.1.A1_3p_s_at

Hs.6947.1.S1_3p_s_at

ILMN_1662809

ILMN_1769473

PH_hs_0000705

TC03001364.hg

g7661773_3p_a_at

g7661773_3p_x_at

Inferred To

SETD2 [nucleoplasm] (Bos taurus)

SETD2 [nucleoplasm] (Canis familiaris)

SETD2 [nucleoplasm] (Mus musculus)

SETD2 [nucleoplasm] (Sus scrofa)

Setd2 [nucleoplasm] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

2702

OpenTargets

ENSG00000181555

ENSEMBL

ENSP00000386759, ENST00000409792

ZINC - Substances

SETD2_HUMAN

ZINC target

Q9BYW2

PRO

Q9BYW2

GlyGen

Q9BYW2

PDB

5LSS, 7LZD, 2MDC, 5LSZ, 6VDB, 7LZB, 5LT6, 5LT8, 5LT7, 8Q5P, 2A7O, 5LSX, 5LSY, 5JJY, 6J9J, 7EA8, 4H12, 5JLE, 7TY3, 4FMU, 7TY2, 5V22, 5V21, 7EVS, 5JLB, 2MDJ, 2MDI, 7EVR, 7LZF

HPA

ENSG00000181555-SETD2

Pharos - Targets

Q9BYW2

Orphanet

SETD2

ZINC - Predictions - Purchasable

SETD2_HUMAN

HMDB Protein

HMDBP09035

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449627 REP			0.547	2
UniProt:P00740 F9	20	F9(227-461) R384L [plasma membrane] (R-HSA-9668263) 3OHD110-F9(29-461) N43L [endoplasmic reticulum lumen] (R-HSA-9673207) 3OHD110-F9(29-461) N46S [endoplasmic reticulum lumen] (R-HSA-9673232) 3OHD110-F9(29-461) N43Q [endoplasmic reticulum lumen] (R-HSA-9673217) 3OHD110-F9(29-461) N43W [endoplasmic reticulum lumen] (R-HSA-9673235) 12xCbxE-3D-F9(47-461) R191H [extracellular region] (R-HSA-9673404) F9(29-461) R43Q [extracellular region] (R-HSA-9673228) F9(29-461) R43W [extracellular region] (R-HSA-9673213) 12xCbxE-3D-F9(47-461) R191C [extracellular region] (R-HSA-9673391) F9(29-461) R46S [extracellular region] (R-HSA-9673193) 12xCbxE-3D-F9(47-461) R226W [extracellular region] (R-HSA-9673403) F9(29-461) R43L [extracellular region] (R-HSA-9673205) 12xCbxE-3D-F9(47-461) R226Q [extracellular region] (R-HSA-9673415) 12xCbxE-3D-F9(47-461) R226G [extracellular region] (R-HSA-9673418) F9(227-461) G409V [plasma membrane] (R-HSA-9671020) F9(227-461) I443T [plasma membrane] (R-HSA-9670908) F9(227-461) S411G [plasma membrane] (R-HSA-9671021) F9(227-461) G363E [plasma membrane] (R-HSA-9670894) F9(227-461) G363R [plasma membrane] (R-HSA-9670862) F9(227-461) D410H [plasma membrane] (R-HSA-9671007)	0.527	2
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	3
UniProt:P49760 CLK2			0.527	2
UniProt:Q5VWQ0 RSBN1			0.527	2
UniProt:Q9UJY1 HSPB8	1	HSPB8 [nucleoplasm] (R-HSA-6806337)	0.527	3
UniProt:Q9GZY0 NXF2	2	NXF2 [cytosol] (R-HSA-8932924) NXF2 [nucleoplasm] (R-HSA-8932926)	0.527	2
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.508	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368) CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987)	0.483	2

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