Reactome | DHX8 [nucleoplasm]

DHX8 [nucleoplasm]

Stable Identifier

R-HSA-5688092

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ATP-dependent RNA helicase DHX8, DHX8_HUMAN, hPrp22, HRH1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14562 DHX8

Gene Names

DHX8, DDX8

Chain

chain:1-1220

Reference Genes

BioGPS Gene:1659 DHX8

COSMIC (genes):DHX8 DHX8

CTD Gene:1659 DHX8

dbSNP Gene:1659 DHX8

ENSEMBL:ENSG00000067596 DHX8

ENSEMBL_homo_sapiens_GENE:ENSG00000067596.12 DHX8

HGNC:2749 DHX8

KEGG Gene (Homo sapiens):1659 DHX8

Monarch:1659 DHX8

NCBI Gene:1659 DHX8

OMIM:600396 DHX8

UCSC:Q14562 DHX8

Reference Transcript

Other Identifiers

11752098_a_at

11757750_a_at

11757826_a_at

1659

16834634

203334_PM_at

203334_at

227079_PM_at

227079_at

3722555

3722556

3722560

3722561

3722562

3722563

3722565

3722566

3722567

3722568

3722569

3722570

3722571

3722572

3722574

3722575

3722576

3722577

3722579

3722580

3722584

3722585

3722586

3722587

3722590

3722591

3722592

3722593

3722594

3722595

43074_at

744_at

8007505

87989_at

A_14_P122239

A_14_P139593

A_23_P124224

D50487_at

GE57244

GO:0000166

GO:0000390

GO:0000398

GO:0003676

GO:0003723

GO:0003724

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005681

GO:0005829

GO:0006396

GO:0006397

GO:0008186

GO:0008380

GO:0016071

GO:0016604

GO:0016787

GO:0016887

GO:0042802

GO:0043226

GO:0071007

GO:0071013

GO:0140098

GO:0140657

HMNXSV003011405

HMNXSV003014691

Hs.171872.1.S1_3p_s_at

ILMN_1687419

PH_hs_0010288

PH_hs_0041103

TC17000556.hg

TC17002218.hg

g4826689_3p_at

Participates

as an input of

Formation of the Spliceosomal C* complex (Homo sapiens)

as a component of

as an output of

Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)

Inferred To

Dhx8 [nucleoplasm] (Rattus norvegicus)

dhx8 [nucleoplasm] (Xenopus tropicalis)

DHX8 [nucleoplasm] (Bos taurus)

DHX8 [nucleoplasm] (Caenorhabditis elegans)

DHX8 [nucleoplasm] (Canis familiaris)

DHX8 [nucleoplasm] (Dictyostelium discoideum)

DHX8 [nucleoplasm] (Drosophila melanogaster)

DHX8 [nucleoplasm] (Gallus gallus)

DHX8 [nucleoplasm] (Mus musculus)

DHX8 [nucleoplasm] (Plasmodium falciparum)

DHX8 [nucleoplasm] (Schizosaccharomyces pombe)

DHX8 [nucleoplasm] (Sus scrofa)

Ghost homologue of DHX8 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_004932.1, NP_001289552.1

OpenTargets

ENSG00000067596

IntEnz

3.6.4.13

HPA

ENSG00000067596-DHX8

GeneCards

Q14562

Ensembl

ENSP00000262415, ENST00000650571, ENSG00000067596, ENSP00000496923, ENST00000262415

PRO

Q14562

Pharos - Targets

Q14562

HMDB Protein

HMDBP11706

PDB

7W59, 6QDV, 5MQF, 5XJC, 6HYU, 6ICZ, 3I4U, 7W5B, 6HYT, 2EQS, 8C6J, 7W5A, 6HYS

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.59	2
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.528	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.508	2
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.508	2
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.508	2
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.508	2
UniProt:Q83B01 Q83B01			0.488	2
UniProt:P0DTD1-PRO_0000449633 REP			0.488	2

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