Reactome | RBBP6 [cytosol]

RBBP6 [cytosol]

Stable Identifier

R-HSA-8850895

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase RBBP6 ecNumber6.3.2.-/ecNumber, RBBP6_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB1 GTPase cycle (Homo sapiens)
        
        RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        RBBP6 [cytosol] (Homo sapiens)
        
        RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        RBBP6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z6E9 RBBP6

Gene Names

RBBP6, P2PR, PACT, RBQ1, My038

Chain

chain:1-1792

Reference Genes

BioGPS Gene:5930 RBBP6

COSMIC - genes:RBBP6 RBBP6

CTD Gene:5930 RBBP6

dbSNP Gene:5930 RBBP6

ENSEMBL:ENSG00000122257 RBBP6

HGNC:9889 RBBP6

KEGG:hsa:5930 RBBP6

Monarch:5930 RBBP6

NCBI Gene:5930 RBBP6

OMIM:600938 RBBP6

UCSC:Q7Z6E9 RBBP6

Reference Transcript

Participates

as a candidate of

RHOBTB1 interacting proteins [cytosol] (Homo sapiens)

as a member of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Other forms of this molecule

RBBP6 [nucleoplasm]

Inferred To

MPE1 [cytosol] (Saccharomyces cerevisiae)

rbbp6 [cytosol] (Danio rerio)

rbbp6 [cytosol] (Xenopus tropicalis)

rbpl-1 [cytosol] (Caenorhabditis elegans)

snama [cytosol] (Drosophila melanogaster)

RBBP6 [cytosol] (Bos taurus)

RBBP6 [cytosol] (Canis familiaris)

RBBP6 [cytosol] (Dictyostelium discoideum)

RBBP6 [cytosol] (Gallus gallus)

RBBP6 [cytosol] (Schizosaccharomyces pombe)

RBBP6 [cytosol] (Sus scrofa)

Rbbp6 [cytosol] (Mus musculus)

Rbbp6 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_061173.1, NP_008841.2, NP_116015.2

OpenTargets

ENSG00000122257

ENSEMBL

ENSP00000317872, ENSP00000370427, ENST00000319715, ENSG00000122257, ENST00000452655, ENSP00000390537, ENSP00000316291, ENST00000381039, ENST00000348022

HPA

ENSG00000122257-RBBP6

GeneCards

RBBP6

PRO

Q7Z6E9

Pharos - Targets

Q7Z6E9

GlyGen

Q7Z6E9

PDB

2YSA, 3ZTG, 6E5X, 2YUR, 2C7H

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.655	4
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.643	3
UniProt:Q9H609 ZN576			0.643	4
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.643	4
UniProt:Q8TEL6 TRPC4AP	1	TRPC4AP [plasma membrane] (R-HSA-3211767)	0.643	4
UniProt:Q15287 RNPS1	2	RNPS1 [cytosol] (R-HSA-159256) RNPS1 [nucleoplasm] (R-HSA-156778)	0.643	5
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.527	3
UniProt:P49761 CLK3			0.527	3
UniProt:P49760 CLK2			0.527	2
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.527	2
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.527	2
UniProt:Q9UL40 ZN346			0.527	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2

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