CDK7 [nucleoplasm]

Stable Identifier
R-HSA-69218
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdk7, Cell division protein kinase 7 (EC 2.7.1.-) (CDK-activating kinase) (CAK)(TFIIH) (basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15)(STK1)(CAK1), Cell division protein kinase 7 , CDK-activating kinase, CAK, TFIIH basal transcription factor complex kinase subunit, 39 kDa protein kinase, P39 Mo15, STK1, CAK1
Locations in the PathwayBrowser
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External Reference Information
External Reference
UniProt:P50613 CDK7
Gene Names
CDK7, CAK, CAK1, CDKN7, MO15, STK1
Chain
initiator methionine:, chain:2-346
Reference Genes
BioGPS Gene:1022 CDK7
COSMIC (genes):CDK7 CDK7
CTD Gene:1022 CDK7
dbSNP Gene:1022 CDK7
ENSEMBL:ENSG00000134058 CDK7
HGNC:1778 CDK7
KEGG:hsa:1022 CDK7
Monarch:1022 CDK7
NCBI Gene:1022 CDK7
OMIM:601955 CDK7
UCSC:P50613 CDK7
Reference Transcript
Other Identifiers
1022
11717845_a_at
16985637
1969_s_at
211297_PM_s_at
211297_s_at
2813483
2813484
2813485
2813486
2813489
2813490
2813492
2813493
2813494
2813495
2813496
2813498
2813499
2813500
2813503
2813505
2813506
2813507
2813508
33317_at
8105862
8177462
A_14_P115402
A_14_P126498
A_23_P133585
GE79229
GO:0000307
GO:0000439
GO:0001650
GO:0001673
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005675
GO:0005737
GO:0005829
GO:0005886
GO:0006281
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006367
GO:0006468
GO:0008094
GO:0008353
GO:0016073
GO:0016301
GO:0016740
GO:0042795
GO:0043226
GO:0045944
GO:0048471
GO:0050821
GO:0051301
GO:0051726
GO:0070516
GO:0070985
GO:0106310
GO:0140096
GO:0140097
GO:0140657
GO:2000045
HMNXSV003054204
ILMN_1778917
L20320_at
PH_hs_0027953
TC05000301.hg
g348242_3p_a_at
Participates
as an input of
as a component of
Inferred To
Ghost homologue of CDK7 [nucleoplasm] (Plasmodium falciparum)
CDK7 [nucleoplasm] (Bos taurus)
CDK7 [nucleoplasm] (Caenorhabditis elegans)
CDK7 [nucleoplasm] (Canis familiaris)
CDK7 [nucleoplasm] (Danio rerio)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Drosophila melanogaster)
CDK7 [nucleoplasm] (Gallus gallus)
CDK7 [nucleoplasm] (Mus musculus)
CDK7 [nucleoplasm] (Rattus norvegicus)
CDK7 [nucleoplasm] (Saccharomyces cerevisiae)
CDK7 [nucleoplasm] (Schizosaccharomyces pombe)
CDK7 [nucleoplasm] (Sus scrofa)
CDK7 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Investigational
IntEnz
HPA
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (29)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P51946 CCNH  1 0.943 19
 UniProt:P51948 MNAT1  1 0.899 15
 UniProt:P19447 ERCC3  1 0.848 9
 UniProt:P18074 ERCC2  2 0.848 11
 UniProt:P32780 GTF2H1  1 0.816 8
 UniProt:Q92759 GTF2H4  1 0.802 8
 UniProt:P28715 ERCC5  1 0.802 8
 UniProt:Q6ZYL4 GTF2H5  1 0.802 8
 UniProt:Q13889 GTF2H3  1 0.745 7
 UniProt:P24941 CDK2  5 0.713 3
 UniProt:Q13888 GTF2H2  1 0.671 9
 UniProt:P08238 HSP90AB1  6 0.669 4
 UniProt:Q6P1K8 T2H2L      0.643 3
 UniProt:P78362 SRPK2  1 0.59 2
 UniProt:Q96SB4 SRPK1  2 0.59 2
 UniProt:Q16543 CDC37  1 0.569 5
 UniProt:P14635 CCNB1  4 0.527 2
 UniProt:Q13451 FKBP5  2 0.527 3
 UniProt:O96006 ZBED1  1 0.527 2
 UniProt:P46527 CDKN1B  8 0.527 3
 UniProt:Q86X55 CARM1  1 0.527 2
 UniProt:Q8IZL9 CDK20      0.527 3
 UniProt:Q13137 CACO2      0.527 2
 UniProt:P20248 CCNA2  5 0.527 2
 UniProt:P24864 CCNE1  3 0.527 2
 UniProt:Q58FF6 H90B4      0.527 3
 UniProt:Q58FG0 HS905      0.527 3
 UniProt:Q58FG1 HS904      0.527 3
 UniProt:P46013 KI67      0.483 3
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