Reactome | SRSF3 [nucleoplasm]

SRSF3 [nucleoplasm]

Stable Identifier

R-HSA-72035

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SRp20, Splicing factor, arginine/serine-rich 3 (Pre-mRNA splicing factor SRP20) (X16 protein), Splicing factor, arginine/serine-rich 3, Pre-mRNA splicing factor SRP20, X16 protein

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Growing Transcript in the Termination Region (Homo sapiens)
      - Cleavage of mRNA at the 3'-end (Homo sapiens)
        
        3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        SRSF3 [nucleoplasm] (Homo sapiens)
        
        Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        SRSF3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P84103 SRSF3

Gene Names

SRSF3, SFRS3, SRP20

Chain

chain:1-164

Reference Genes

BioGPS Gene:6428 SRSF3

COSMIC (genes):SRSF3 SRSF3

CTD Gene:6428 SRSF3

dbSNP Gene:6428 SRSF3

ENSEMBL:ENSG00000112081 SRSF3

ENSEMBL_homo_sapiens_GENE:ENSG00000112081 SRSF3

HGNC:10785 SRSF3

KEGG Gene (Homo sapiens):6428 SRSF3

Monarch:6428 SRSF3

NCBI Gene:6428 SRSF3

OMIM:603364 SRSF3

UCSC:P84103 SRSF3

Reference Transcript

RefSeq:NM_003017.4 SRSF3

Other Identifiers

0005550347

11723038_at

11723039_x_at

11753649_s_at

11753650_x_at

11755128_s_at

11757962_s_at

12986

17007996

202899_s_at

208672_s_at

208673_s_at

235324_at

2905120

2905122

2905124

2905126

2905127

2905128

2905129

2905130

2905132

2905134

2905136

2905137

2905138

2905139

2905140

2905141

2905142

2I2Y

2I38

3322896

3322900

3322903

351_f_at

40457_at

56981

6428

73345_at

81061_at

8119080

A0A087X2D0

A_14_P137284

A_23_P413761

A_33_P3232828

AAA36648

AAD44523

AAH00914

AAH69018

AAP35663

AB451229

AB451352

AF107405

AK304097

AK312553

B2R6F3

BAG35450

BAG65003

BAG70043

BAG70166

BC000914

BC069018

BT007017

CAB012986

CCDS4823

CH471081

D28423_at

EAX03898

EAX03901

EAX03903

ENSG00000112081

ENSP00000362820

ENSP00000436036

ENSP00000482833

ENST00000373715

ENST00000477442

ENST00000620941

EntrezGene:6428

g12654192_3p_a_at

g4506900_3p_s_at

g5531903_3p_a_at

GE80149

GE86492

GO:0000381

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0006397

GO:0006405

GO:0006406

GO:0006810

GO:0006913

GO:0008150

GO:0008380

GO:0016607

GO:0031124

GO:0034641

GO:0043226

GO:0045292

GO:0048024

GO:0051028

GO:1990825

HGNC:10785

HPA056981

Hs.115315.0.A1_3p_at

ILMN_1723212

ILMN_2135232

IPR000504

IPR012677

IPR035979

L10838

L10838_at

MIM:603364

NM_003017

NP_003008

NR_036610

PF00076

PH_hs_0006320

PH_hs_0024643

SM00360

SRSF3

SRSF3-202

SRSF3-203

SRSF3-208

TC06000530.hg

TC06002757.hg

uc003omj.4

uc063oel.1

uc063oem.1

UPI0000004131

UPI000002B379

Z85986

Participant Of

input

Formation of the Spliceosomal E complex

output

Docking of the TAP:EJC Complex with the NPC

hasComponent

Inferred To

Homologues of SRSF3 [nucleoplasm] (Arabidopsis thaliana)

Homologues of SRSF3 [nucleoplasm] (Danio rerio)

Homologues of SRSF3 [nucleoplasm] (Drosophila melanogaster)

Homologues of SRSF3 [nucleoplasm] (Oryza sativa)

Homologues of SRSF3 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of SRSF3 [nucleoplasm] (Canis familiaris)

Ghost homologue of SRSF3 [nucleoplasm] (Gallus gallus)

SRSF3 [nucleoplasm] (Arabidopsis thaliana)

SRSF3 [nucleoplasm] (Bos taurus)

SRSF3 [nucleoplasm] (Caenorhabditis elegans)

SRSF3 [nucleoplasm] (Danio rerio)

SRSF3 [nucleoplasm] (Drosophila melanogaster)

SRSF3 [nucleoplasm] (Mus musculus)

SRSF3 [nucleoplasm] (Oryza sativa)

SRSF3 [nucleoplasm] (Rattus norvegicus)

SRSF3 [nucleoplasm] (Sus scrofa)

SRSF3 [nucleoplasm] (Taeniopygia guttata)

SRSF3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_003008.1

OpenTargets

ENSG00000112081

GeneCards

P84103

PRO

P84103

PDB

2I38, 2I2Y

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.641	3
UniProt:Q15366 PCBP2	2	PCBP2 [nucleoplasm] (R-HSA-71921) PCBP2 [cytosol] (R-HSA-983457)	0.581	3
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.544	4
UniProt:Q64368 DAZL			0.527	2
UniProt:Q9JKL7 SREK1			0.499	3
UniProt:P57721-2 PCBP3			0.488	2
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.488	2
UniProt:Q14011 CIRBP			0.488	2
UniProt:Q9Y5E9 PCDBE			0.488	2
UniProt:Q8NE01 CNNM3			0.488	2
UniProt:P49761 CLK3			0.488	2
UniProt:P0DN76 U2AF5			0.488	2
UniProt:P26368-2 U2AF2			0.488	2
UniProt:Q9BRL6-2 SRSF8			0.488	2
UniProt:P98179 RBM3			0.488	2
UniProt:P61978-2 HNRNPK			0.488	2
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372)	0.488	2
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2
UniProt:P49760 CLK2			0.488	2
UniProt:P32969 RPL9	1	RPL9 [cytosol] (R-HSA-72492)	0.488	2
UniProt:P49759-3 CLK1			0.488	2
UniProt:P38159 RBMX	1	RBMX [nucleoplasm] (R-HSA-71939)	0.488	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.462	2
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.462	2