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SRSF3 [nucleoplasm]
Stable Identifier
R-HSA-72035
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SRp20, Splicing factor, arginine/serine-rich 3 (Pre-mRNA splicing factor SRP20) (X16 protein), Splicing factor, arginine/serine-rich 3, Pre-mRNA splicing factor SRP20, X16 protein
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Formation of Exon Junction Complex (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Formation of an intermediate Spliceosomal C complex (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal A Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Formation of the active Spliceosomal C complex (Homo sapiens)
Spliceosomal Active C Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)
Spliceosomal Active C Complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
SRSF3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P84103 SRSF3
Gene Names
SRSF3, SFRS3, SRP20
Chain
chain:1-164
Reference Genes
BioGPS Gene:6428 SRSF3
COSMIC (genes):SRSF3 SRSF3
CTD Gene:6428 SRSF3
dbSNP Gene:6428 SRSF3
ENSEMBL:ENSG00000112081 SRSF3
HGNC:10785 SRSF3
KEGG Gene (Homo sapiens):6428 SRSF3
Monarch:6428 SRSF3
NCBI Gene:6428 SRSF3
OMIM:603364 SRSF3
UCSC:P84103 SRSF3
Reference Transcript
RefSeq:NM_003017.4 SRSF3
Other Identifiers
0005550347
11723038_at
11723039_x_at
11753649_s_at
11753650_x_at
11755128_s_at
11757962_s_at
17007996
202899_s_at
208672_s_at
208673_s_at
235324_at
2766463
2905119
2905120
2905122
2905124
2905126
2905127
2905128
2905129
2905130
2905132
2905134
2905136
2905137
2905138
2905139
2905140
2905141
2905142
2905143
3322896
3322900
3322903
351_f_at
40457_at
6428
73345_at
81061_at
8119080
89302_at
A_14_P137284
A_23_P413761
A_33_P3232828
D28423_at
GE752945
GE80149
GE86492
GO:0000398
GO:0003674
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0006397
GO:0006405
GO:0006406
GO:0006810
GO:0006913
GO:0008150
GO:0008380
GO:0015031
GO:0016607
GO:0019899
GO:0031124
GO:0034641
GO:0043226
GO:0043274
GO:0048024
GO:0051028
GO:1990825
GO:1990830
HMNXSV003030847
Hs.115315.0.A1_3p_at
ILMN_1723212
ILMN_2135232
L10838_at
PH_hs_0006320
PH_hs_0024643
TC06000530.hg
TC06002757.hg
g12654192_3p_a_at
g4506900_3p_s_at
g5531903_3p_a_at
Participates
as an input of
Formation of the Spliceosomal E complex (Homo sapiens)
as a component of
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
Spliceosomal Active C Complex [nucleoplasm] (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
as an output of
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
Inferred To
rsp-6 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of SRSF3 [nucleoplasm]
(Drosophila melanogaster)
Rbp1 [nucleoplasm]
(Drosophila melanogaster)
Rbp1-like [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of SRSF3 [nucleoplasm]
(Dictyostelium discoideum)
Srsf3 [nucleoplasm]
(Mus musculus)
Srsf3 [nucleoplasm]
(Rattus norvegicus)
srsf3b [nucleoplasm]
(Danio rerio)
SRSF3 [nucleoplasm]
(Canis familiaris)
SRSF3 [nucleoplasm]
(Gallus gallus)
SRSF3 [nucleoplasm]
(Schizosaccharomyces pombe)
SRSF3 [nucleoplasm]
(Sus scrofa)
srsf3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003008.1
OpenTargets
ENSG00000112081
GeneCards
P84103
HPA
ENSG00000112081-SRSF3
Ensembl
ENSP00000362820
,
ENST00000373715
,
ENSP00000482833
,
ENSP00000436036
,
ENST00000477442
,
ENST00000620941
,
ENSG00000112081
PRO
P84103
Pharos - Targets
P84103
GlyGen
P84103
PDB
2I38
,
2I2Y
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01081 U2AF1
1
U2AF1 [nucleoplasm]
(R-HSA-71985)
0.659
4
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.641
3
UniProt:P09429 HMGB1
5
HMGB1 [secretory granule lumen]
(R-HSA-6803337)
HMGB1 [ficolin-1-rich granule lumen]
(R-HSA-6803291)
HMGB1 [extracellular region]
(R-HSA-879382)
HC23,45-HMGB1 [extracellular region]
(R-HSA-6797422)
HMGB1 [nucleoplasm]
(R-HSA-266221)
0.613
3
UniProt:Q15366 PCBP2
2
PCBP2 [nucleoplasm]
(R-HSA-71921)
PCBP2 [cytosol]
(R-HSA-983457)
0.581
3
UniProt:P57721-2 PCBP3
0.556
3
UniProt:Q15287 RNPS1
2
RNPS1 [nucleoplasm]
(R-HSA-156778)
RNPS1 [cytosol]
(R-HSA-159256)
0.556
3
UniProt:Q14011 CIRBP
0.556
3
UniProt:P38159 RBMX
2
RBMX [nucleoplasm]
(R-HSA-71939)
RBMX [cytosol]
(R-HSA-9715135)
0.556
3
UniProt:Q9Y5E9 PCDBE
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:P49759-3 CLK1
0.556
3
UniProt:P32969 RPL9
1
RPL9 [cytosol]
(R-HSA-72492)
0.556
3
UniProt:P49760 CLK2
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q8WWY3 PRPF31
1
PRPF31 [nucleoplasm]
(R-HSA-6806772)
0.556
3
UniProt:P61978-2 HNRNPK
0.556
3
UniProt:P98179 RBM3
0.556
3
UniProt:Q9BRL6-2 SRSF8
0.556
3
UniProt:P26368-2 U2AF2
0.556
3
UniProt:P49761 CLK3
0.556
3
UniProt:Q8NE01 CNNM3
0.556
3
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.544
4
UniProt:Q64368 DAZL
0.527
2
UniProt:Q9JKL7 SREK1
0.499
3
UniProt:P61326 MAGOH
1
MAGOH [nucleoplasm]
(R-HSA-156658)
0.462
2
UniProt:P38919 EIF4A3
2
EIF4A3 [cytosol]
(R-HSA-927868)
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
0.462
2
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