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DZIP3 [cytosol]
Stable Identifier
R-HSA-976002
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase DZIP3, DZIP3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DZIP3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86Y13 DZIP3
Gene Names
DZIP3, KIAA0675
Chain
chain:1-1208
Reference Genes
BioGPS Gene:9666 DZIP3
COSMIC (genes):DZIP3 DZIP3
CTD Gene:9666 DZIP3
dbSNP Gene:9666 DZIP3
ENSEMBL:ENSG00000198919.13 DZIP3
HGNC:30938 DZIP3
KEGG Gene (Homo sapiens):9666 DZIP3
Monarch:9666 DZIP3
NCBI Gene:9666 DZIP3
OMIM:608672 DZIP3
UCSC:Q86Y13 DZIP3
Reference Transcript
RefSeq:XM_005247917.3 DZIP3
RefSeq:XM_005247916.3 DZIP3
RefSeq:XM_005247915.3 DZIP3
RefSeq:XM_005247914.3 DZIP3
RefSeq:XM_017007540.1 DZIP3
RefSeq:XM_005247918.3 DZIP3
RefSeq:NM_014648.3 DZIP3
Other Identifiers
0005900594
11732285_at
11732286_a_at
11732287_at
11749677_a_at
11752563_a_at
16943681
207231_PM_at
207231_at
207232_PM_s_at
207232_s_at
213186_PM_at
213186_at
2635264
2635265
2635270
2635272
2635273
2635275
2635276
2635278
2635280
2635281
2635282
2635283
2635284
2635285
2635286
2635287
2635288
2635289
2635290
2635291
2635293
2635294
2635295
2635300
2635301
2635304
2635307
2635308
2635314
2635316
2635318
2635320
2635323
2635324
2635326
2635330
2635331
2635332
2635335
2635336
2635337
2635338
32131_at
32132_at
58870_r_at
8081503
9666
A_14_P103807
A_14_P117901
A_14_P131328
A_23_P144165
A_23_P435051
A_24_P102504
A_33_P3267651
GE53382
GO:0000209
GO:0003723
GO:0004842
GO:0005515
GO:0005622
GO:0005737
GO:0016567
GO:0016740
GO:0019902
GO:0031593
GO:0036211
GO:0046872
GO:0061630
GO:0140096
HMNXSV003017315
Hs.165662.1.S1_3p_at
ILMN_1763200
PH_hs_0041059
TC03000548.hg
g7662243_3p_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
DZIP3 [cytosol]
(Bos taurus)
DZIP3 [cytosol]
(Canis familiaris)
DZIP3 [cytosol]
(Sus scrofa)
Dzip3 [cytosol]
(Mus musculus)
Dzip3 [cytosol]
(Rattus norvegicus)
rnf214 [cytosol]
(Xenopus tropicalis)
si:dkey-111e8.1 [cytosol]
(Danio rerio)
Cross References
RefSeq
XP_005247975.1
,
XP_005247974.1
,
XP_005247973.1
,
XP_005247972.1
,
NP_055463.1
,
XP_005247971.1
,
XP_016863029.1
OpenTargets
ENSG00000198919
IntEnz
2.3.2.27
GeneCards
Q86Y13
HPA
ENSG00000198919-DZIP3
Ensembl
ENST00000361582
,
ENSP00000418871
,
ENST00000463306
,
ENSP00000419981
,
ENSG00000198919
,
ENST00000495008
,
ENSP00000355028
PRO
Q86Y13
Pharos - Targets
Q86Y13
HMDB Protein
HMDBP09329
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52597 HNRNPF
2
HNRNPF [plasma membrane]
(R-HSA-8950714)
HNRNPF [nucleoplasm]
(R-HSA-71937)
0.718
6
UniProt:O95429 BAG4
3
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4(1-126):FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.556
3
UniProt:Q9H0E2 TOLLIP
4
TOLLIP [cytosol]
(R-HSA-446885)
TOLLIP [azurophil granule lumen]
(R-HSA-6799709)
TOLLIP [extracellular region]
(R-HSA-6800448)
TOLLIP [specific granule lumen]
(R-HSA-6799719)
0.499
2
UniProt:P61088 UBE2N
5
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
UBE2N [nucleoplasm]
(R-HSA-5682541)
UBE2N [cytosol]
(R-HSA-206072)
0.488
2
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.488
2
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