Reactome | AMFR [endoplasmic reticulum membrane]

AMFR [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-975999

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

E3 ubiquitin-protein ligase AMFR, AMFR2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UKV5 AMFR

Gene Names

AMFR, RNF45

Chain

chain:1-643

Reference Genes

BioGPS Gene:267 AMFR

COSMIC (genes):AMFR AMFR

CTD Gene:267 AMFR

dbSNP Gene:267 AMFR

ENSEMBL:ENSG00000159461 AMFR

HGNC:463 AMFR

KEGG:hsa:267 AMFR

Monarch:267 AMFR

NCBI Gene:267 AMFR

OMIM:603243 AMFR

UCSC:Q9UKV5 AMFR

Reference Transcript

Other Identifiers

11717261_a_at

11756087_a_at

16826692

202203_PM_s_at

202203_s_at

202204_PM_s_at

202204_s_at

267

3692857

3692858

3692859

3692860

3692861

3692862

3692863

3692864

3692865

3692866

3692869

3692870

3692871

3692874

3692876

3692877

3692878

3692879

3692880

3692881

3692883

3692884

3692885

3692886

3692890

3692891

3692892

3692893

3692894

38068_at

8001477

87138_at

A_23_P141005

A_24_P135444

GE58024

GO:0000151

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006511

GO:0007165

GO:0007249

GO:0007611

GO:0008270

GO:0016020

GO:0016055

GO:0016567

GO:0016740

GO:0030163

GO:0030425

GO:0030426

GO:0030674

GO:0030968

GO:0032991

GO:0034450

GO:0036503

GO:0036513

GO:0038023

GO:0038061

GO:0042802

GO:0043025

GO:0043130

GO:0044314

GO:0044322

GO:0046872

GO:0048471

GO:0050877

GO:0051087

GO:0051865

GO:0060090

GO:0061630

GO:0070936

GO:0090090

GO:0140096

GO:1901135

GO:1904288

GO:1904380

GO:1990381

GO:2000638

HMNXSV003008026

ILMN_1666258

ILMN_1723116

M63175_at

PH_hs_0023564

TC16001132.hg

g5931954_3p_a_at

Participates

as a component of

Deglycosylation complex [endoplasmic reticulum membrane] (Homo sapiens)

as a member of

ERAD E3 ligases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

amfra [endoplasmic reticulum membrane] (Danio rerio)

Ghost homologue of AMFR [endoplasmic reticulum membrane] (Drosophila melanogaster)

hrdl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Amfr [endoplasmic reticulum membrane] (Mus musculus)

Amfr [endoplasmic reticulum membrane] (Rattus norvegicus)

amfr [endoplasmic reticulum membrane] (Xenopus tropicalis)

AMFR [endoplasmic reticulum membrane] (Bos taurus)

AMFR [endoplasmic reticulum membrane] (Canis familiaris)

AMFR [endoplasmic reticulum membrane] (Gallus gallus)

AMFR [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001310441.1, NP_001135.3

ENSEMBL

ENSP00000290649, ENSG00000159461, ENST00000290649

OpenTargets

ENSG00000159461

GeneCards

AMFR

HPA

ENSG00000159461-AMFR

PRO

Q9UKV5

Pharos - Targets

Q9UKV5

HMDB Protein

HMDBP09276

PDB

3H8K, 3FSH, 2LXH, 2LVO, 2LVN, 2LVQ, 2LVP, 8T0S, 2EJS, 3TIW, 4LAD, 2LXP, 4G3O

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.874	12
UniProt:P61077 UBE2D3	3	Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [cytosol] (R-HSA-934630) UBE2D3 [nucleoplasm] (R-HSA-205341)	0.553	2
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) UBE2D2 [cytosol] (R-HSA-934628) UBE2D2 [nucleoplasm] (R-HSA-8852067) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153)	0.553	2
UniProt:P61088 UBE2N	5	UBE2N [cytosol] (R-HSA-206072) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) UBE2N [nucleoplasm] (R-HSA-5682541) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013)	0.553	2
UniProt:P51668 UBE2D1	4	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160) Ub-C85-UBE2D1 [nucleoplasm] (R-HSA-8937534)	0.553	2
UniProt:O76082 SLC22A5	7	SLC22A5 [plasma membrane] (R-HSA-549319) SLC22A5 W132* [plasma membrane] (R-HSA-5625620) SLC22A5 R169Q [plasma membrane] (R-HSA-5625654) SLC22A5 R169W [plasma membrane] (R-HSA-5625686) SLC22A5 R254* [plasma membrane] (R-HSA-5625665) SLC22A5 G15W [plasma membrane] (R-HSA-5625680) SLC22A5 P478L [plasma membrane] (R-HSA-5625661)	0.527	2

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