Reactome | K63polyUb-BIRC3 [cytosol]

K63polyUb-BIRC3 [cytosol]

Stable Identifier

R-HSA-5668478

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K63polyUb-cIAP2

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External Reference Information

External Reference

UniProt:Q13489 BIRC3

Gene Names

BIRC3, API2, MIHC, RNF49

Chain

chain:1-604

Reference Genes

BioGPS Gene:330 BIRC3

COSMIC (genes):BIRC3 BIRC3

CTD Gene:330 BIRC3

dbSNP Gene:330 BIRC3

ENSEMBL:ENSG00000023445 BIRC3

ENSEMBL_homo_sapiens_GENE:ENSG00000023445.17 BIRC3

HGNC:591 BIRC3

KEGG Gene (Homo sapiens):330 BIRC3

Monarch:330 BIRC3

NCBI Gene:330 BIRC3

OMIM:601721 BIRC3

UCSC:Q13489 BIRC3

Reference Transcript

Other Identifiers

11722850_a_at

11722851_at

11722852_s_at

16730522

1717_s_at

210538_PM_s_at

210538_s_at

230499_PM_at

230499_at

330

3346545

3346546

3346547

3346549

3346550

3346553

3346554

3346555

3346556

3346558

3346560

3346561

3346563

3346564

3346566

3346567

3346569

3346570

3346571

3346572

3346573

3346574

3346575

3346576

3346577

3346578

3346580

3346581

63769_at

7943413

88714_at

91017_at

A_14_P125254

A_23_P98350

GE58248

GO:0002376

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006915

GO:0006954

GO:0007166

GO:0007249

GO:0007283

GO:0012501

GO:0016740

GO:0022414

GO:0023052

GO:0031398

GO:0032991

GO:0033209

GO:0034121

GO:0036211

GO:0038061

GO:0039535

GO:0042981

GO:0043027

GO:0043066

GO:0043123

GO:0043226

GO:0044877

GO:0045088

GO:0046872

GO:0050727

GO:0051726

GO:0060544

GO:0060546

GO:0061630

GO:0070424

GO:0098542

GO:0098772

GO:0140096

GO:2000116

HMNXSV003039716

HMNXSV003047151

Hs.121572.0.A1_3p_at

ILMN_1681644

ILMN_1776181

ILMN_2405684

PH_hs_0007351

TC11000956.hg

U37546_s_at

U45878_s_at

g1145290_3p_a_at

Participates

as a member of

K63polyUb-cIAP1,2 [cytosol] (Homo sapiens)

Other forms of this molecule

BIRC3 [cytosol]

K48pUb-BIRC3 [cytosol]

Inferred To

Birc3 [cytosol] (Rattus norvegicus)

K63polyUb-BIRC3 [cytosol] (Canis familiaris)

K63polyUb-BIRC3 [cytosol] (Gallus gallus)

K63polyUb-BIRC3 [cytosol] (Mus musculus)

K63polyUb-BIRC3 [cytosol] (Sus scrofa)

BIRC3 [cytosol] (Bos taurus)

birc2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_892007.1, NP_001156.1, XP_016873132.1

Guide to Pharmacology - Targets

2792

OpenTargets

ENSG00000023445

ZINC - Substances

BIRC3_HUMAN

ZINC target

Q13489

PRO

Q13489

PDB

3EB5, 3M0A, 3M0D, 3EB6, 7NK0, 2UVL

ZINC - Investigational

BIRC3_HUMAN

GeneCards

Q13489

HPA

ENSG00000023445-BIRC3

Ensembl

ENSG00000023445, ENST00000263464, ENST00000526421, ENSP00000501119, ENST00000532808, ENSP00000263464, ENSP00000432907

Pharos - Targets

Q13489

Orphanet

18436

ZINC - Predictions - Purchasable

BIRC3_HUMAN

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.865	8
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.669	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.615	3
UniProt:O43353 RIPK2	2	RIPK2 [cytosol] (R-HSA-168402) Ub-209-RIPK2 [cytosol] (R-HSA-706483)	0.602	3
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.602	3
UniProt:Q9Y572 RIPK3	8	p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933) K33polyUb-K197,302,364-RIPK3 [cytosol] (R-HSA-9794180) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) RIPK3(329-518) [cytosol] (R-HSA-9686937) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825)	0.602	3
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) UBE2N [cytosol] (R-HSA-206072)	0.592	2
UniProt:P22314 UBA1	2	UBA1 [cytosol] (R-HSA-947698) UBA1 [nucleoplasm] (R-HSA-8852116)	0.59	2
UniProt:P55211 CASP9	5	p-S196-CASP9(1-416) [cytosol] (R-HSA-198636) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) CASP9(331-416) [cytosol] (R-HSA-141639) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(1-416) [cytosol] (R-HSA-57033)	0.519	2

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