Reactome | ZNRF1 [cytosol]

ZNRF1 [cytosol]

Stable Identifier

R-HSA-8850903

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase ZNRF1 ecNumber6.3.2.-/ecNumber, ZNRF1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8ND25 ZNRF1

Gene Names

ZNRF1, NIN283

Chain

initiator methionine:, chain:2-227

Reference Genes

BioGPS Gene:84937 ZNRF1

COSMIC (genes):ZNRF1 ZNRF1

CTD Gene:84937 ZNRF1

dbSNP Gene:84937 ZNRF1

ENSEMBL:ENSG00000186187 ZNRF1

ENSEMBL_homo_sapiens_GENE:ENSG00000186187.12 ZNRF1

HGNC:18452 ZNRF1

Monarch:84937 ZNRF1

NCBI Gene:84937 ZNRF1

OMIM:612060 ZNRF1

UCSC:Q8ND25 ZNRF1

Reference Transcript

Other Identifiers

11732356_at

11732357_s_at

11732358_x_at

11732359_a_at

11746939_a_at

16821047

223382_PM_s_at

223382_s_at

223383_PM_at

223383_at

225959_PM_s_at

225959_s_at

225962_PM_at

225962_at

3668835

3668836

3668837

3668857

3668860

3668867

3668873

3668874

3668876

3668877

3668878

3668879

3668880

3668881

3668882

3668883

3668884

3668885

3668886

3668887

46582_at

52988_at

57579_at

7997247

84937

A_23_P163858

A_24_P16610

A_24_P193624

A_24_P262221

GE80726

GO:0002376

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005764

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0016020

GO:0016567

GO:0016740

GO:0023052

GO:0030163

GO:0030672

GO:0031410

GO:0034145

GO:0036211

GO:0043161

GO:0043226

GO:0043231

GO:0045202

GO:0046872

GO:0061630

GO:0070936

GO:0098542

GO:0140096

HMNXSV003035873

Hs.49657.1.A2_3p_at

Hs.49657.1.A3_3p_at

ILMN_1742775

PH_hs_0016039

TC16000615.hg

g12053302_3p_s_at

Participates

as a member of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

Znrf1 [cytosol] (Mus musculus)

Znrf1 [cytosol] (Rattus norvegicus)

znrf1 [cytosol] (Danio rerio)

znrf1 [cytosol] (Xenopus tropicalis)

Dmel\CG14435 [cytosol] (Drosophila melanogaster)

ZNRF1 [cytosol] (Bos taurus)

ZNRF1 [cytosol] (Caenorhabditis elegans)

ZNRF1 [cytosol] (Canis familiaris)

ZNRF1 [cytosol] (Dictyostelium discoideum)

ZNRF1 [cytosol] (Gallus gallus)

ZNRF1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_115644.1, XP_016879282.1

OpenTargets

ENSG00000186187

IntEnz

2.3.2.27

GeneCards

Q8ND25

HPA

ENSG00000186187-ZNRF1

Ensembl

ENSP00000323362, ENST00000335325, ENST00000567962, ENSG00000186187, ENSP00000335091, ENST00000320619, ENSP00000455601

PRO

Q8ND25

Pharos - Targets

Q8ND25

PDB

5YWR

HMDB Protein

HMDBP09320

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.788	9
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) UBE2N [cytosol] (R-HSA-206072)	0.766	5
UniProt:P61077 UBE2D3	3	Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [cytosol] (R-HSA-934630) UBE2D3 [nucleoplasm] (R-HSA-205341)	0.621	3
UniProt:O94888 WIPF1	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.556	5