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ZNRF1 [cytosol]
Stable Identifier
R-HSA-8850903
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase ZNRF1 ecNumber6.3.2.-/ecNumber, ZNRF1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8ND25 ZNRF1
Gene Names
ZNRF1, NIN283
Chain
initiator methionine:, chain:2-227
Reference Genes
BioGPS Gene:84937 ZNRF1
COSMIC (genes):ZNRF1 ZNRF1
CTD Gene:84937 ZNRF1
dbSNP Gene:84937 ZNRF1
ENSEMBL:ENSG00000186187 ZNRF1
HGNC:18452 ZNRF1
KEGG:hsa:84937 ZNRF1
Monarch:84937 ZNRF1
NCBI Gene:84937 ZNRF1
OMIM:612060 ZNRF1
UCSC:Q8ND25 ZNRF1
Reference Transcript
RefSeq:XM_017023793.1 ZNRF1
RefSeq:NM_032268.4 ZNRF1
Other Identifiers
11732356_at
11732357_s_at
11732358_x_at
11732359_a_at
11746939_a_at
16821047
223382_PM_s_at
223382_s_at
223383_PM_at
223383_at
225959_PM_s_at
225959_s_at
225960_PM_at
225960_at
225962_PM_at
225962_at
3668835
3668836
3668837
3668838
3668843
3668857
3668860
3668867
3668868
3668869
3668870
3668871
3668872
3668873
3668874
3668875
3668876
3668877
3668878
3668879
3668880
3668881
3668882
3668883
3668884
3668885
3668886
3668887
46582_at
52988_at
57579_at
7997247
84937
A_23_P163858
A_24_P16610
A_24_P193624
A_24_P262221
GE80726
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0016020
GO:0016567
GO:0016740
GO:0030163
GO:0030672
GO:0031410
GO:0034145
GO:0043161
GO:0043226
GO:0043231
GO:0045202
GO:0046872
GO:0061630
GO:0070936
GO:0140096
GO:0160177
HMNXSV003035873
Hs.49657.1.A1_3p_at
Hs.49657.1.A2_3p_at
Hs.49657.1.A3_3p_at
ILMN_1742775
PH_hs_0016039
TC16000615.hg
g12053302_3p_s_at
Participates
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Znrf1 [cytosol]
(Mus musculus)
Znrf1 [cytosol]
(Rattus norvegicus)
znrf1 [cytosol]
(Danio rerio)
znrf1 [cytosol]
(Xenopus tropicalis)
ZNRF1 [cytosol]
(Bos taurus)
ZNRF1 [cytosol]
(Caenorhabditis elegans)
ZNRF1 [cytosol]
(Canis familiaris)
ZNRF1 [cytosol]
(Dictyostelium discoideum)
ZNRF1 [cytosol]
(Gallus gallus)
ZNRF1 [cytosol]
(Sus scrofa)
detr [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016879282.1
,
NP_115644.1
ENSEMBL
ENSP00000323362
,
ENST00000335325
,
ENST00000567962
,
ENSP00000455601
,
ENSP00000335091
,
ENST00000320619
OpenTargets
ENSG00000186187
IntEnz
2.3.2.27
HPA
ENSG00000186187-ZNRF1
PRO
Q8ND25
Pharos - Targets
Q8ND25
HMDB Protein
HMDBP09320
PDB
5YWR
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61088 UBE2N
5
UBE2N [cytosol]
(R-HSA-206072)
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
UBE2N [nucleoplasm]
(R-HSA-5682541)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
0.822
7
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.788
9
UniProt:P61077 UBE2D3
3
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
UBE2D3 [cytosol]
(R-HSA-934630)
UBE2D3 [nucleoplasm]
(R-HSA-205341)
0.621
3
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.556
5
UniProt:O60551 NMT2
1
NMT2 [cytosol]
(R-HSA-184377)
0.527
3
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