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phospho-chico [cytosol]
Stable Identifier
R-DME-74772
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-Y-IRS1, Q9XTN2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
SOS-mediated signalling (Drosophila melanogaster)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
Signal attenuation (Drosophila melanogaster)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Drosophila melanogaster)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
SOS-mediated signalling (Drosophila melanogaster)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
phospho-chico [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9XTN2 chico
Gene Names
chico, IRS, CG5686
Chain
chain:1-968
Reference Genes
BioGPS Gene:64880 chico
KEGG Gene (Drosophila melanogaster):Dmel_CG5686 chico
Monarch:64880 chico
NCBI Gene:64880 chico
UCSC:Q9XTN2 chico
Reference Transcript
RefSeq:NM_001273387.1 chico
RefSeq:NM_164899.3 chico
RefSeq:NM_001201843.2 chico
Other Identifiers
152360_at
1631374_at
64880
GO:0002376
GO:0005158
GO:0005159
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005938
GO:0006629
GO:0007165
GO:0007285
GO:0007295
GO:0007296
GO:0007568
GO:0008284
GO:0008286
GO:0008340
GO:0008355
GO:0009267
GO:0010897
GO:0014068
GO:0022414
GO:0023052
GO:0030154
GO:0034059
GO:0035159
GO:0035264
GO:0040018
GO:0042169
GO:0042593
GO:0042594
GO:0043226
GO:0043231
GO:0043491
GO:0043548
GO:0045793
GO:0045927
GO:0046622
GO:0048009
GO:0048133
GO:0048477
GO:0048856
GO:0048870
GO:0050778
GO:0050877
GO:0051897
GO:0055088
GO:0060250
GO:0060291
GO:0061964
GO:1903688
Participates
as an output of
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Drosophila melanogaster)
as a component of
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
as an input of
p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)
Other forms of this molecule
CHICO [cytosol]
Phospho CHICO [cytosol]
chico [cytosol]
chico [cytosol]
phospho-chico [cytosol]
phospho-chico [plasma membrane]
phospho-chico [plasma membrane]
Inferred From
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Homo sapiens)
p-Y-IRS1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001188772.1
,
NP_001260316.1
,
NP_723540.1
Flybase
FBgn0024248
PRO
Q9XTN2
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09208 InR
10
INR beta subunit [plasma membrane]
(R-DME-110421)
phospho-insulin receptor beta subunit [plasma membrane]
(R-DME-110423)
INR alpha subunit [plasma membrane]
(R-DME-110420)
phospho-p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-DME-2404172)
IGF1R(31-736) [plasma membrane]
(R-DME-2404169)
phospho-p-6Y-INSR(763-1382) [endosome membrane]
(R-DME-141719)
INSR(763-1382) [endosome membrane]
(R-DME-141722)
INSR(28-758) [endosome membrane]
(R-DME-141718)
INSR(763-1382) [plasma membrane]
(R-DME-74669)
INSR(28-758) [plasma membrane]
(R-DME-74668)
0.564
3
UniProt:O18683 Pi3K21B
1
PI3K21B [cytosol]
(R-DME-110433)
0.508
3
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