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p-Y-IRS1,p-Y-IRS2 [cytosol]
Stable Identifier
R-HSA-112322
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
JAK2 phosphorylation of IRS-1/2 (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Signaling by Leptin (Homo sapiens)
JAK2 Phosphorylates IRS in Response to Leptin (Homo sapiens)
LEP:p-LEPR:p-JAK2:SH2B1:p-IRS1,2 [plasma membrane] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS activation (Homo sapiens)
Dissociation of IRS-P from insulin receptor (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Phosphorylation of IRS (Homo sapiens)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
SOS-mediated signalling (Homo sapiens)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Signal attenuation (Homo sapiens)
Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Homo sapiens)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
TRKA phosphorylates IRS (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
SOS-mediated signalling (Homo sapiens)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Participants
members
p-Y-IRS1 [cytosol]
(Homo sapiens)
p-Y-IRS2 [cytosol]
(Homo sapiens)
Participates
as a component of
LEP:p-LEPR:p-JAK2:SH2B1:p-IRS1,2 [plasma membrane] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
as an output of
JAK2 phosphorylation of IRS-1/2 (Homo sapiens)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Homo sapiens)
Dissociation of IRS-P from insulin receptor (Homo sapiens)
as an input of
p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)
Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)
Inferred To
phospho-p-Y-IRS1 [cytosol]
(Gallus gallus)
phospho-chico [cytosol]
(Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Bos taurus)
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Sus scrofa)
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Xenopus tropicalis)
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