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phospho-irs1 [cytosol]
Stable Identifier
R-XTR-74772
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
p-Y-IRS1, A0A6I8SCF3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
MAPK family signaling cascades (Xenopus tropicalis)
MAPK1/MAPK3 signaling (Xenopus tropicalis)
RAF/MAP kinase cascade (Xenopus tropicalis)
RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)
RAS GEFs [plasma membrane] (Xenopus tropicalis)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ALK (Xenopus tropicalis)
Active ALK phosphorylates IRS1 (Xenopus tropicalis)
Active ALK:pY-IRS1 [plasma membrane] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
Signaling by Insulin receptor (Xenopus tropicalis)
Insulin receptor signalling cascade (Xenopus tropicalis)
IRS activation (Xenopus tropicalis)
Dissociation of IRS-P from insulin receptor (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
Phosphorylation of IRS (Xenopus tropicalis)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI3K-containing complexes [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
SOS-mediated signalling (Xenopus tropicalis)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Xenopus tropicalis)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
Signal attenuation (Xenopus tropicalis)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Xenopus tropicalis)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
Signaling by LTK (Xenopus tropicalis)
Active LTK phosphorylates IRS1 (Xenopus tropicalis)
Active LTK:p-Y IRS1 [plasma membrane] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
IRS1 recruits GRB2 to active LTK (Xenopus tropicalis)
Active LTK:p-Y IRS1 [plasma membrane] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
Signaling by NTRKs (Xenopus tropicalis)
Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
PI3K/AKT activation (Xenopus tropicalis)
Active IRS recruits PI3K to the plasma membrane and activates it (Xenopus tropicalis)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Xenopus tropicalis)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Xenopus tropicalis)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Xenopus tropicalis)
IGF1R signaling cascade (Xenopus tropicalis)
IRS-related events triggered by IGF1R (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI3K-containing complexes [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
SOS-mediated signalling (Xenopus tropicalis)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Xenopus tropicalis)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
phospho-irs1 [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:A0A6I8SCF3
Gene Names
irs1
Reference Genes
BioGPS Gene:100495320 irs1
ENSEMBL:ENSXETG00000020086
KEGG:xtr:100495320 irs1
Monarch:100495320 irs1
NCBI Gene:100495320 irs1
UCSC:A0A6I8SCF3 irs1
Reference Transcript
RefSeq:XM_002937088.4 irs1
Other Identifiers
100495320
GO:0005102
GO:0005158
GO:0005829
GO:0005886
GO:0007165
GO:0008286
GO:0009967
GO:0030159
GO:0043548
GO:0060090
Participates
as a component of
Active ALK:pY-IRS1 [plasma membrane] (Xenopus tropicalis)
Active LTK:p-Y IRS1 [plasma membrane] (Xenopus tropicalis)
as a member of
p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
Other forms of this molecule
phospho-irs1 [plasma membrane]
irs1 [plasma membrane]
irs1 [cytosol]
phospho-irs1 [plasma membrane]
Inferred From
p-Y-IRS1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_002937134.1
ENSEMBL
ENSXETT00000073884
,
ENSXETG00000020086
,
ENSXETP00000090937
Xenbase
XB-GENE-478672
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