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phospho-p-Y-IRS1 [cytosol]
Stable Identifier
R-GGA-74772
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
F1NIJ3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
RAS GEFs [plasma membrane] (Gallus gallus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
Active ALK phosphorylates IRS1 (Gallus gallus)
Active ALK:pY-IRS1 [plasma membrane] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS activation (Gallus gallus)
Dissociation of IRS-P from insulin receptor (Gallus gallus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
Phosphorylation of IRS (Gallus gallus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
SOS-mediated signalling (Gallus gallus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Gallus gallus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
Signal attenuation (Gallus gallus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Gallus gallus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
Signaling by LTK (Gallus gallus)
Active LTK phosphorylates IRS1 (Gallus gallus)
Active LTK:p-Y IRS1 [plasma membrane] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
IRS1 recruits GRB2 to active LTK (Gallus gallus)
Active LTK:p-Y IRS1 [plasma membrane] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
PI3K/AKT activation (Gallus gallus)
Active IRS recruits PI3K to the plasma membrane and activates it (Gallus gallus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Gallus gallus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
SOS-mediated signalling (Gallus gallus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Gallus gallus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
phospho-p-Y-IRS1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NIJ3
Reference Genes
ENSEMBL:ENSGALG00000004959
Participates
as a component of
Active ALK:pY-IRS1 [plasma membrane] (Gallus gallus)
Active LTK:p-Y IRS1 [plasma membrane] (Gallus gallus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Gallus gallus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Gallus gallus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Gallus gallus)
as an output of
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Gallus gallus)
Dissociation of IRS-P from insulin receptor (Gallus gallus)
as an input of
p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Gallus gallus)
Other forms of this molecule
phospho-p-6Y-IRS1 [plasma membrane]
IRS1 [plasma membrane]
IRS1 [cytosol]
phospho-p-Y-IRS1 [plasma membrane]
Inferred From
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Homo sapiens)
p-Y-IRS1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
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