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phospho-irs1 [cytosol]
Stable Identifier
R-DRE-74772
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
p-Y-IRS1, E7F4P8
Locations in the PathwayBrowser
Expand all
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS GEFs promote RAS nucleotide exchange (Danio rerio)
RAS GEFs [plasma membrane] (Danio rerio)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ALK (Danio rerio)
Active ALK phosphorylates IRS1 (Danio rerio)
Active ALK:pY-IRS1 [plasma membrane] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
IRS activation (Danio rerio)
Dissociation of IRS-P from insulin receptor (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
Phosphorylation of IRS (Danio rerio)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
SOS-mediated signalling (Danio rerio)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Danio rerio)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
Signal attenuation (Danio rerio)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Danio rerio)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Danio rerio)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
Signaling by LTK (Danio rerio)
Active LTK phosphorylates IRS1 (Danio rerio)
Active LTK:p-Y IRS1 [plasma membrane] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
IRS1 recruits GRB2 to active LTK (Danio rerio)
Active LTK:p-Y IRS1 [plasma membrane] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
PI3K/AKT activation (Danio rerio)
Active IRS recruits PI3K to the plasma membrane and activates it (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Danio rerio)
IGF1R signaling cascade (Danio rerio)
IRS-related events triggered by IGF1R (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
SOS-mediated signalling (Danio rerio)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Danio rerio)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs1 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:E7F4P8
Gene Names
irs1
Reference Genes
BioGPS Gene:559281 irs1
ENSEMBL:ENSDARG00000054087
KEGG:dre:559281 irs1
Monarch:559281 irs1
NCBI Gene:559281 irs1
UCSC:E7F4P8 irs1
Reference Transcript
RefSeq:XM_682610.10 irs1
Other Identifiers
13027449
559281
A_15_P114072
A_15_P165796
A_15_P341800
A_15_P383190
A_15_P483075
CJ011337
CJ011338
CJ011341
CJ012429
CJ012816
CJ013283
CJ013406
CJ013597
CJ013614
CUST_9589_PI428451953
DRER10567
ENSDART00000076229
ENSDART00000076229_1
GO:0005158
GO:0008286
GT_Spec_XM_682610.6_165276
JP011475
LOLS13244
XM_682610
Participates
as a component of
Active ALK:pY-IRS1 [plasma membrane] (Danio rerio)
Active LTK:p-Y IRS1 [plasma membrane] (Danio rerio)
as a member of
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
Other forms of this molecule
irs1 [cytosol]
phospho-irs1 [plasma membrane]
Inferred From
p-Y-IRS1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_687702.4
ENSEMBL
ENSDARG00000054087
,
ENSDARP00000070706
,
ENSDART00000076229
ZFIN
ZDB-GENE-030131-872
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