TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

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Homo sapiens
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The exact mechanisms of action of several other pro-apoptotic TP53 (p53) targets, such as TP53I3 (PIG3), RABGGTA, BCL2L14, BCL6, NDRG1 and PERP, remain uncertain (Attardi et al. 2000, Guo et al. 2001, Samuels-Lev et al. 2001, Contente et al. 2002, Ihrie et al. 2003, Bergamaschi et al. 2004, Stein et al. 2004, Phan and Dalla-Favera 2004, Jen and Cheung 2005, Margalit et al. 2006, Zhang et al. 2007, Saito et al. 2009, Davies et al. 2009, Giam et al. 2012).

Literature References
PubMed ID Title Journal Year
11054413 Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

Godzik, A, Reed, JC, Guo, B

J. Biol. Chem. 2001
10733530 PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

Attardi, LD, Jacks, T, Cosmas, C, McCurrach, ME, Demicco, EG, Lowe, SW, Reczek, EE

Genes Dev. 2000
16249378 BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma

Shohat, M, Shaklai, S, Amariglio, N, Margalit, O, Granot, G, Givol, D, Minsky, N, Harmelin, A, Simon, AJ, Amram, H, Rechavi, G, Shimoni, A, Oren, M

Blood 2006
15377670 NDRG1 is necessary for p53-dependent apoptosis

Herzog, B, Liang, P, Jackson, RS, Thomas, EK, Wang, M, Westfall, MD, Rocheleau, JV, Stein, S

J. Biol. Chem. 2004
23059823 Bcl-2 family member Bcl-G is not a proapoptotic protein

Bouillet, P, Giam, M, Strasser, A, Mintern, JD, Okamoto, T

Cell Death Dis 2012
15577913 The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

Dalla-Favera, R, Phan, RT

Nature 2004
14729977 ASPP1 and ASPP2: common activators of p53 family members

Samuels, Y, Lu, X, Jin, B, Duraisingham, S, Bergamaschi, D, Crook, T

Mol. Cell. Biol. 2004
19549844 BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

Chadburn, A, Basso, K, Dalla-Favera, R, Bhagat, G, Sumazin, P, Shen, Q, Saito, M, Novak, U, Pasqualucci, L, Crespo, M, Piovan, E, Califano, A, Schneider, C

Proc. Natl. Acad. Sci. U.S.A. 2009
17442733 p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion

Liu, L, Chen, J, Xiao, L, Wang, JY, Zou, T, Turner, DJ, Marasa, BS, Zhang, AH, Rao, JN

Am. J. Physiol., Cell Physiol. 2007
11919562 A polymorphic microsatellite that mediates induction of PIG3 by p53

Dobbelstein, M, Roth, J, Koch, MC, Dittmer, A, Contente, A

Nat. Genet. 2002
14614825 Perp is a mediator of p53-dependent apoptosis in diverse cell types

Horner, JS, Jacks, T, Sage, J, Attardi, LD, Reczek, E, Khachatrian, L, Ihrie, RA

Curr. Biol. 2003
19040420 P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma

Paraoan, L, Spiller, D, Grierson, I, White, MR, Gray, D, Davies, L, Damato, B

J. Cell. Mol. Med. 2009
16140933 Identification of novel p53 target genes in ionizing radiation response

Jen, KY, Cheung, VG

Cancer Res. 2005
11684014 ASPP proteins specifically stimulate the apoptotic function of p53

Hsieh, JK, Trigiante, G, Crook, T, Zhong, S, Bergamaschi, D, O'Connor, DJ, Lu, X, Campargue, I, Naumovski, L, Samuels-Lev, Y

Mol. Cell 2001
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