TP53 or TP63 binds the PERP gene

Stable Identifier
R-HSA-6800836
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The PERP gene possesses two p53 response elements in its promoter region and at least one p53 response element in its first intron, which are involved in the recruitment of TP53 (p53) or TP63 (p63) to the PERP gene locus (Attardi et al. 2000, Ihrie et al. 2005).

Literature References
PubMed ID Title Journal Year
10733530 PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

Attardi, LD, Reczek, EE, Cosmas, C, Demicco, EG, McCurrach, ME, Lowe, SW, Jacks, T

Genes Dev. 2000
15797384 Perp is a p63-regulated gene essential for epithelial integrity

Ihrie, RA, Marques, MR, Nguyen, BT, Horner, JS, Papazoglu, C, Bronson, RT, Mills, AA, Attardi, LD

Cell 2005
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