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TP53 binds the RABGGTA gene
Stable Identifier
R-HSA-6801087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
TP53 binds the RABGGTA gene (Homo sapiens)
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The RABGGTA gene possesses three p53 response elements, one in the promoter and two downstream of the transcription start site. TP53 (p53) can bind, at least, to the promoter p53 response element of the RABGGTA gene (Jen and Cheung 2005).
Literature References
PubMed ID
Title
Journal
Year
16140933
Identification of novel p53 target genes in ionizing radiation response
Jen, KY
,
Cheung, VG
Cancer Res.
2005
Participants
Input
p-S15,S20-TP53 Tetramer [nucleoplasm]
(Homo sapiens)
RABGGTA Gene [nucleoplasm]
(Homo sapiens)
Output
p-S15,S20-TP53 Tetramer:RABGGTA Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
Authored
Orlic-Milacic, M (2015-10-14)
Reviewed
Zaccara, S (2016-02-04)
Inga, A (2016-02-04)
Created
Orlic-Milacic, M (2015-09-30)
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