Reactome | TP53 binds the RABGGTA gene

TP53 binds the RABGGTA gene

Stable Identifier

R-HSA-6801087

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 binds the RABGGTA gene (Homo sapiens)

General

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The RABGGTA gene possesses three p53 response elements, one in the promoter and two downstream of the transcription start site. TP53 (p53) can bind, at least, to the promoter p53 response element of the RABGGTA gene (Jen and Cheung 2005).

Literature References

PubMed ID	Title	Journal	Year
16140933	Identification of novel p53 target genes in ionizing radiation response Jen, KY, Cheung, VG	Cancer Res.	2005

Participants

Input

Output

p-S15,S20-TP53 Tetramer:RABGGTA Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-09-30)

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