Reactome | TP53 stimulates BCL6 expression

TP53 stimulates BCL6 expression

Stable Identifier

R-HSA-6800250

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 stimulates BCL6 expression (Homo sapiens)

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Binding of TP53 (p53) to the p53 response element in the first intron of the BCL6 gene promotes BCL6 transcription (Margalit et al. 2006). BCL6 is a transcriptional repressor that has been implicated as a facilitator of apoptosis, through inhibition of BCL2 expression (Saito et al. 2009), but also as an inhibitor of apoptosis, through inhibition of TP53 expression (Phan and Dalla-Favera 2004).

Literature References

PubMed ID	Title	Journal	Year
15577913	The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells Phan, RT, Dalla-Favera, R	Nature	2004
19549844	BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma Saito, M, Novak, U, Piovan, E, Basso, K, Sumazin, P, Schneider, C, Crespo, M, Shen, Q, Bhagat, G, Califano, A, Chadburn, A, Pasqualucci, L, Dalla-Favera, R	Proc. Natl. Acad. Sci. U.S.A.	2009
16249378	BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma Margalit, O, Amram, H, Amariglio, N, Simon, AJ, Shaklai, S, Granot, G, Minsky, N, Shimoni, A, Harmelin, A, Givol, D, Shohat, M, Oren, M, Rechavi, G	Blood	2006