Binding of TP53 (p53) to the p53 response element in the first intron of the BCL6 gene promotes BCL6 transcription (Margalit et al. 2006). BCL6 is a transcriptional repressor that has been implicated as a facilitator of apoptosis, through inhibition of BCL2 expression (Saito et al. 2009), but also as an inhibitor of apoptosis, through inhibition of TP53 expression (Phan and Dalla-Favera 2004).
Phan, RT, Dalla-Favera, R
Saito, M, Novak, U, Piovan, E, Basso, K, Sumazin, P, Schneider, C, Crespo, M, Shen, Q, Bhagat, G, Califano, A, Chadburn, A, Pasqualucci, L, Dalla-Favera, R
Margalit, O, Amram, H, Amariglio, N, Simon, AJ, Shaklai, S, Granot, G, Minsky, N, Shimoni, A, Harmelin, A, Givol, D, Shohat, M, Oren, M, Rechavi, G
© 2021 Reactome
