Binding of TP53 (p53) to the p53 response element in the first intron of the BCL6 gene promotes BCL6 transcription (Margalit et al. 2006). BCL6 is a transcriptional repressor that has been implicated as a facilitator of apoptosis, through inhibition of BCL2 expression (Saito et al. 2009), but also as an inhibitor of apoptosis, through inhibition of TP53 expression (Phan and Dalla-Favera 2004).
Chadburn, A, Basso, K, Dalla-Favera, R, Bhagat, G, Sumazin, P, Shen, Q, Saito, M, Novak, U, Pasqualucci, L, Crespo, M, Piovan, E, Califano, A, Schneider, C
Dalla-Favera, R, Phan, RT
Shohat, M, Shaklai, S, Amariglio, N, Margalit, O, Granot, G, Givol, D, Minsky, N, Harmelin, A, Simon, AJ, Amram, H, Rechavi, G, Shimoni, A, Oren, M
© 2022 Reactome
