TP53 family members bind the TP53I3 (PIG3) gene promoter

Stable Identifier
R-HSA-6799462
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 family members bind the TP53I3 (PIG3) gene promoter
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TP53 (p53) binds a pentanucleotide microsatellite sequence in the promoter of the TP53I3 (PIG3) gene that shares a limited similarity with the consensus sequence of the p53 response element (Contente et al. 2002). TP63 (p63) and TP73 (p73), members of the p53 protein family, can also bind the promoter of TP53I3 (Bergamaschi et al. 2004). Formation of a complex between p53 family members and ASSP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) enhances binding of TP53 (Samuels-Lev et al. 2001), TP63 or TP73 to the TP53I3 promoter (Bergamaschi et al. 2004).
Literature References
PubMed ID Title Journal Year
11684014 ASPP proteins specifically stimulate the apoptotic function of p53

Hsieh, JK, Trigiante, G, Crook, T, Zhong, S, Bergamaschi, D, O'Connor, DJ, Lu, X, Campargue, I, Naumovski, L, Samuels-Lev, Y

Mol. Cell 2001
14729977 ASPP1 and ASPP2: common activators of p53 family members

Samuels, Y, Lu, X, Jin, B, Duraisingham, S, Bergamaschi, D, Crook, T

Mol. Cell. Biol. 2004
11919562 A polymorphic microsatellite that mediates induction of PIG3 by p53

Dobbelstein, M, Roth, J, Koch, MC, Dittmer, A, Contente, A

Nat. Genet. 2002
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Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-24)
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