TP53 family members bind the TP53I3 (PIG3) gene promoter

Stable Identifier
R-HSA-6799462
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TP53 (p53) binds a pentanucleotide microsatellite sequence in the promoter of the TP53I3 (PIG3) gene that shares a limited similarity with the consensus sequence of the p53 response element (Contente et al. 2002). TP63 (p63) and TP73 (p73), members of the p53 protein family, can also bind the promoter of TP53I3 (Bergamaschi et al. 2004). Formation of a complex between p53 family members and ASSP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) enhances binding of TP53 (Samuels-Lev et al. 2001), TP63 or TP73 to the TP53I3 promoter (Bergamaschi et al. 2004).

Literature References
PubMed ID Title Journal Year
14729977 ASPP1 and ASPP2: common activators of p53 family members

Bergamaschi, D, Samuels, Y, Jin, B, Duraisingham, S, Crook, T, Lu, X

Mol. Cell. Biol. 2004
11684014 ASPP proteins specifically stimulate the apoptotic function of p53

Samuels-Lev, Y, O'Connor, DJ, Bergamaschi, D, Trigiante, G, Hsieh, JK, Zhong, S, Campargue, I, Naumovski, L, Crook, T, Lu, X

Mol. Cell 2001
11919562 A polymorphic microsatellite that mediates induction of PIG3 by p53

Contente, A, Dittmer, A, Koch, MC, Roth, J, Dobbelstein, M

Nat. Genet. 2002
Participants
Participant Of
Authored
Reviewed
Created