TP53I3 oxidoreductase generates unstable semiquinones

Stable Identifier
R-HSA-6799722
Type
Reaction
Species
Homo sapiens
Compartment
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TP53I3 (PIG3) possesses a NADPH quinone reductase activity, with 1,2-naphthoquinone being its preferred substrate. TP53I3 reduces 1,2-naphthoquinone to a highly unstable semiquinone free radical. Semiquinone reacts with oxygen yielding a quinone and superoxide aninon. Reactive oxygen species (ROS) produced as a result of TP53I3 activity contribute to apoptosis (Porte et al. 2009).

Literature References
PubMed ID Title Journal Year
19349281 Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3

Parés, X, Debreczeny, JE, Valencia, E, Shafqat, N, Porté, S, Fita, I, Oppermann, U, Yakovtseva, EA, Farrés, J, Pike, AC, Borràs, E

J. Biol. Chem. 2009
Participants
Participates
Catalyst Activity

NADPH:quinone reductase activity of TP53I3 Dimer [cytosol]

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