Reactome | TP53I3 oxidoreductase generates unstable semiquinones

TP53I3 oxidoreductase generates unstable semiquinones

Stable Identifier

R-HSA-6799722

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)

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TP53I3 oxidoreductase generates unstable semiquinones

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TP53I3 (PIG3) possesses a NADPH quinone reductase activity, with 1,2-naphthoquinone being its preferred substrate. TP53I3 reduces 1,2-naphthoquinone to a highly unstable semiquinone free radical. Semiquinone reacts with oxygen yielding a quinone and superoxide aninon. Reactive oxygen species (ROS) produced as a result of TP53I3 activity contribute to apoptosis (Porte et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19349281	Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3 Parés, X, Debreczeny, JE, Valencia, E, Shafqat, N, Porté, S, Fita, I, Oppermann, U, Yakovtseva, EA, Farrés, J, Pike, AC, Borràs, E	J. Biol. Chem.	2009