TP53I3 (PIG3) possesses a NADPH quinone reductase activity, with 1,2-naphthoquinone being its preferred substrate. TP53I3 reduces 1,2-naphthoquinone to a highly unstable semiquinone free radical. Semiquinone reacts with oxygen yielding a quinone and superoxide aninon. Reactive oxygen species (ROS) produced as a result of TP53I3 activity contribute to apoptosis (Porte et al. 2009).
Parés, X, Debreczeny, JE, Valencia, E, Shafqat, N, Porté, S, Fita, I, Oppermann, U, Yakovtseva, EA, Farrés, J, Pike, AC, Borràs, E
NADPH:quinone reductase activity of TP53I3 Dimer [cytosol]
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