TP53I3 oxidoreductase generates unstable semiquinones

Stable Identifier
R-HSA-6799722
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TP53I3 (PIG3) possesses a NADPH quinone reductase activity, with 1,2-naphthoquinone being its preferred substrate. TP53I3 reduces 1,2-naphthoquinone to a highly unstable semiquinone free radical. Semiquinone reacts with oxygen yielding a quinone and superoxide aninon. Reactive oxygen species (ROS) produced as a result of TP53I3 activity contribute to apoptosis (Porte et al. 2009).

Literature References
PubMed ID Title Journal Year
19349281 Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3

Porté, S, Valencia, E, Yakovtseva, EA, Borràs, E, Shafqat, N, Debreczeny, JE, Pike, AC, Oppermann, U, Farrés, J, Fita, I, Parés, X

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NADPH:quinone reductase activity of TP53I3 Dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created