Reactome | TP53 stimulates expression of the TP53I3 (PIG3) gene

TP53 stimulates expression of the TP53I3 (PIG3) gene

Stable Identifier

R-HSA-6799441

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)

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TP53 stimulates expression of the TP53I3 (PIG3) gene

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TP53 (p53) activates transcription of the TP53I3 (PIG3) gene by binding to the pentanucleotide microsatellite sequence in the TP53I3 gene promoter that shares a limited similarity with the consensus p53 response element (Contente et al. 2002). Transcription of the TP53I3 gene can also be activated by p53 family members TP63 (p63) and TP73 (p73) (Bergamaschi et al. 2004). ASPP proteins PPP1R13B (ASPP1) and TP53BP2 (ASPP2) form a complex with p53 family members, leading to increased binding of p53 family members to the TP53I3 promoter and enhanced transcription of TP53I3 (Samuels-Lev et al. 2001, Bergamaschi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
11684014	ASPP proteins specifically stimulate the apoptotic function of p53 Hsieh, JK, Trigiante, G, Crook, T, Zhong, S, Bergamaschi, D, O'Connor, DJ, Lu, X, Campargue, I, Naumovski, L, Samuels-Lev, Y	Mol. Cell	2001
14729977	ASPP1 and ASPP2: common activators of p53 family members Samuels, Y, Lu, X, Jin, B, Duraisingham, S, Bergamaschi, D, Crook, T	Mol. Cell. Biol.	2004
11919562	A polymorphic microsatellite that mediates induction of PIG3 by p53 Dobbelstein, M, Roth, J, Koch, MC, Dittmer, A, Contente, A	Nat. Genet.	2002