TP53 (p53) activates transcription of the TP53I3 (PIG3) gene by binding to the pentanucleotide microsatellite sequence in the TP53I3 gene promoter that shares a limited similarity with the consensus p53 response element (Contente et al. 2002). Transcription of the TP53I3 gene can also be activated by p53 family members TP63 (p63) and TP73 (p73) (Bergamaschi et al. 2004). ASPP proteins PPP1R13B (ASPP1) and TP53BP2 (ASPP2) form a complex with p53 family members, leading to increased binding of p53 family members to the TP53I3 promoter and enhanced transcription of TP53I3 (Samuels-Lev et al. 2001, Bergamaschi et al. 2004).
Bergamaschi, D, Samuels, Y, Jin, B, Duraisingham, S, Crook, T, Lu, X
Samuels-Lev, Y, O'Connor, DJ, Bergamaschi, D, Trigiante, G, Hsieh, JK, Zhong, S, Campargue, I, Naumovski, L, Crook, T, Lu, X
Contente, A, Dittmer, A, Koch, MC, Roth, J, Dobbelstein, M
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