Reactome | Semiquinone reacts with oxygen

Semiquinone reacts with oxygen

Stable Identifier

R-HSA-6799733

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        Semiquinone reacts with oxygen (Homo sapiens)

General

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Semiquinone spontaneously reacts with oxygen to revert to a quinone state and produces superoxide anion (Oppermann 2007, Porte et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
17009925	Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology Oppermann, U	Annu. Rev. Pharmacol. Toxicol.	2007
19349281	Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3 Porté, S, Valencia, E, Yakovtseva, EA, Borràs, E, Shafqat, N, Debreczeny, JE, Pike, AC, Oppermann, U, Farrés, J, Fita, I, Parés, X	J. Biol. Chem.	2009

Participants

Input

Output

Participant Of

hasEvent

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-09-25)