Reactome | Semiquinone reacts with oxygen

Semiquinone reacts with oxygen

Stable Identifier

R-HSA-6799733

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        Semiquinone reacts with oxygen (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Semiquinone spontaneously reacts with oxygen to revert to a quinone state and produces superoxide anion (Oppermann 2007, Porte et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19349281	Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3 Parés, X, Debreczeny, JE, Valencia, E, Shafqat, N, Porté, S, Fita, I, Oppermann, U, Yakovtseva, EA, Farrés, J, Pike, AC, Borràs, E	J. Biol. Chem.	2009
17009925	Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology Oppermann, U	Annu. Rev. Pharmacol. Toxicol.	2007

Participants

Input

Output

Participates

as an event of

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-09-25)

Cite Us!