CHM binds RGGT

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAB escort protein CHM (REP1) binds the RAB geranylgeranyl transferase complex, RGGT, composed of RABGGTA and RABGGTB (Baron and Seabra 2008). The interaction between CHM and the RGGT complex is enhanced by the presence of phosphoisoprenoids (Thoma et al. 2001). The complex of RGGT and CHM catalyzes geranylgeranylation of small GTPases RAB1A, RAB3A and RAB5A, which is needed for the membrane localization of RABs (Farnsworth et al. 1994). RAB geranylgeranyl transferase can play an anti-apoptotic role, through an unknown mechanism (Lackner et al. 2005). RAB5A, the substrate of RGGT:CHM complex, was shown to positively regulate formation of autophagosomes (Li et al. 2013).

Literature References
PubMed ID Title Journal Year
15837622 Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

Franke, Y, Keegan, K, Guan, B, Brown, K, Lee, JM, Perez-Villar, JJ, Reddy, RK, Ross-Macdonald, P, Costa, M, Xiao, H, Carroll, PM, Cockett, M, de Silva, H, O'Brien, C, Parry, D, Manne, V, Chen, C, Plowman, G, Lackner, MR, Heuer, T, Zhan, H, Hung, T, Fitzgerald, K, Cancilla, MR, Kindt, RM

Cancer Cell 2005
18532927 Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate

Seabra, MC, Baron, RA

Biochem. J. 2008
11675392 Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1

Iakovenko, A, Goody, RS, Thomä, NH, Alexandrov, K

J. Biol. Chem. 2001
7991565 Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

Ericsson, LH, Gelb, MH, Farnsworth, CC, Seabra, MC, Glomset, JA

Proc. Natl. Acad. Sci. U.S.A. 1994
23182941 A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy

Zhao, Y, Ma, D, Xiao, J, Chen, Y, Qu, L, Hu, J, Li, Y, Wang, Z

Autophagy 2013
Orthologous Events
Cite Us!