CHM binds RGGT

Stable Identifier
R-HSA-6801109
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Summation

RAB escort protein CHM (REP1) binds the RAB geranylgeranyl transferase complex, RGGT, composed of RABGGTA and RABGGTB (Baron and Seabra 2008). The interaction between CHM and the RGGT complex is enhanced by the presence of phosphoisoprenoids (Thoma et al. 2001). The complex of RGGT and CHM catalyzes geranylgeranylation of small GTPases RAB1A, RAB3A and RAB5A, which is needed for the membrane localization of RABs (Farnsworth et al. 1994). RAB geranylgeranyl transferase can play an anti-apoptotic role, through an unknown mechanism (Lackner et al. 2005). RAB5A, the substrate of RGGT:CHM complex, was shown to positively regulate formation of autophagosomes (Li et al. 2013).

Literature References
PubMed ID Title Journal Year
18532927 Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate

Baron, RA, Seabra, MC

Biochem. J. 2008
15837622 Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

Lackner, MR, Kindt, RM, Carroll, PM, Brown, K, Cancilla, MR, Chen, C, de Silva, H, Franke, Y, Guan, B, Heuer, T, Hung, T, Keegan, K, Lee, JM, Manne, V, O'Brien, C, Parry, D, Perez-Villar, JJ, Reddy, RK, Xiao, H, Zhan, H, Cockett, M, Plowman, G, Fitzgerald, K, Costa, M, Ross-Macdonald, P

Cancer Cell 2005
11675392 Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1

Thomä, NH, Iakovenko, A, Goody, RS, Alexandrov, K

J. Biol. Chem. 2001
7991565 Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

Farnsworth, CC, Seabra, MC, Ericsson, LH, Gelb, MH, Glomset, JA

Proc. Natl. Acad. Sci. U.S.A. 1994
23182941 A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy

Li, Y, Zhao, Y, Hu, J, Xiao, J, Qu, L, Wang, Z, Ma, D, Chen, Y

Autophagy 2013
Participants
Input
Output
Participant Of
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Orthologous Events
CHM binds RGGT (Arabidopsis thaliana)
CHM binds RGGT (Bos taurus)
CHM binds RGGT (Caenorhabditis elegans)
CHM binds RGGT (Canis familiaris)
CHM binds RGGT (Danio rerio)
CHM binds RGGT (Dictyostelium discoideum)
CHM binds RGGT (Drosophila melanogaster)
CHM binds RGGT (Mus musculus)
CHM binds RGGT (Oryza sativa)
CHM binds RGGT (Rattus norvegicus)
CHM binds RGGT (Saccharomyces cerevisiae)
CHM binds RGGT (Schizosaccharomyces pombe)
CHM binds RGGT (Sus scrofa)
CHM binds RGGT (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)