Reactome | CHM binds RGGT

CHM binds RGGT

Stable Identifier

R-HSA-6801109

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        CHM binds RGGT (Homo sapiens)

General

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RAB escort protein CHM (REP1) binds the RAB geranylgeranyl transferase complex, RGGT, composed of RABGGTA and RABGGTB (Baron and Seabra 2008). The interaction between CHM and the RGGT complex is enhanced by the presence of phosphoisoprenoids (Thoma et al. 2001). The complex of RGGT and CHM catalyzes geranylgeranylation of small GTPases RAB1A, RAB3A and RAB5A, which is needed for the membrane localization of RABs (Farnsworth et al. 1994). RAB geranylgeranyl transferase can play an anti-apoptotic role, through an unknown mechanism (Lackner et al. 2005). RAB5A, the substrate of RGGT:CHM complex, was shown to positively regulate formation of autophagosomes (Li et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
15837622	Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors Franke, Y, Keegan, K, Guan, B, Brown, K, Lee, JM, Perez-Villar, JJ, Reddy, RK, Ross-Macdonald, P, Costa, M, Xiao, H, Carroll, PM, Cockett, M, de Silva, H, O'Brien, C, Parry, D, Manne, V, Chen, C, Plowman, G, Lackner, MR, Heuer, T, Zhan, H, Hung, T, Fitzgerald, K, Cancilla, MR, Kindt, RM	Cancer Cell	2005
18532927	Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate Seabra, MC, Baron, RA	Biochem. J.	2008
11675392	Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1 Iakovenko, A, Goody, RS, Thomä, NH, Alexandrov, K	J. Biol. Chem.	2001
7991565	Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A Ericsson, LH, Gelb, MH, Farnsworth, CC, Seabra, MC, Glomset, JA	Proc. Natl. Acad. Sci. U.S.A.	1994
23182941	A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy Zhao, Y, Ma, D, Xiao, J, Chen, Y, Qu, L, Hu, J, Li, Y, Wang, Z	Autophagy	2013