Binding of TP53 (p53) or TP63 (p63) to p53 response elements in the promoter and/or the first intron of the PERP gene promotes PERP transcription (Attardi et al. 2000, Ihrie et al. 2005). E2F1 may cooperate with TP53 in the transcriptional activation of PERP (Attardi et al. 2000). PERP is a transmembrane protein that specifically localizes to desmosomes and is important for epithelial integrity. PERP is involved in p53-dependent apoptosis (Attardi et al. 2000, Ihrie et al. 2003) and may act through contributing to caspase activation (Davies et al. 2009).
Horner, JS, Nguyen, BT, Papazoglu, C, Marques, MR, Attardi, LD, Bronson, RT, Ihrie, RA, Mills, AA
Paraoan, L, Spiller, D, Grierson, I, White, MR, Gray, D, Davies, L, Damato, B
Horner, JS, Jacks, T, Sage, J, Attardi, LD, Reczek, E, Khachatrian, L, Ihrie, RA
Attardi, LD, Jacks, T, Cosmas, C, McCurrach, ME, Demicco, EG, Lowe, SW, Reczek, EE
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