TP53 or TP63 stimulates PERP gene expression

Stable Identifier
R-HSA-6800816
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TP53 or TP63 stimulates PERP gene expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of TP53 (p53) or TP63 (p63) to p53 response elements in the promoter and/or the first intron of the PERP gene promotes PERP transcription (Attardi et al. 2000, Ihrie et al. 2005). E2F1 may cooperate with TP53 in the transcriptional activation of PERP (Attardi et al. 2000). PERP is a transmembrane protein that specifically localizes to desmosomes and is important for epithelial integrity. PERP is involved in p53-dependent apoptosis (Attardi et al. 2000, Ihrie et al. 2003) and may act through contributing to caspase activation (Davies et al. 2009).
Literature References
PubMed ID Title Journal Year
15797384 Perp is a p63-regulated gene essential for epithelial integrity

Ihrie, RA, Marques, MR, Nguyen, BT, Horner, JS, Papazoglu, C, Bronson, RT, Mills, AA, Attardi, LD

Cell 2005
19040420 P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma

Davies, L, Gray, D, Spiller, D, White, MR, Damato, B, Grierson, I, Paraoan, L

J. Cell. Mol. Med. 2009
14614825 Perp is a mediator of p53-dependent apoptosis in diverse cell types

Ihrie, RA, Reczek, E, Horner, JS, Khachatrian, L, Sage, J, Jacks, T, Attardi, LD

Curr. Biol. 2003
10733530 PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

Attardi, LD, Reczek, EE, Cosmas, C, Demicco, EG, McCurrach, ME, Lowe, SW, Jacks, T

Genes Dev. 2000
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
(p-S15,S20-TP53,TP63):PERP Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53,TP63 [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-29)
Cite Us!