Reactome | TP53 binds the NDRG1 gene promoter

TP53 binds the NDRG1 gene promoter

Stable Identifier

R-HSA-5633295

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 binds the NDRG1 gene promoter (Homo sapiens)

General

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TP53 (p53) binds p53-response element(s) in the promoter of the NDRG1 gene (Stein et al. 2004, Zhang et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17442733	p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion Zhang, AH, Rao, JN, Zou, T, Liu, L, Marasa, BS, Xiao, L, Chen, J, Turner, DJ, Wang, JY	Am. J. Physiol., Cell Physiol.	2007
15377670	NDRG1 is necessary for p53-dependent apoptosis Stein, S, Thomas, EK, Herzog, B, Westfall, MD, Rocheleau, JV, Jackson, RS, Wang, M, Liang, P	J. Biol. Chem.	2004

Participants

Input

Output

p-S15,S20-TP53 Tetramer:NDRG1 Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2014-10-31)

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